2. Apoptosis
  3. Ferroptosis
  4. Chalcones A-N-5

Chalcones A-N-5 是一种三羟基查耳酮衍生物化合物。Chalcones A-N-5 在浓度低于 100 µM (IC50 > 1 mM) 时不显示细胞毒性，但对促进细胞增殖有显着作用。Chalcones A-N-5 可能促进受损脑组织中神经元细胞的生长。Chalcones A-N-5 还抑制由 RSL 或 erastin 诱导的铁死亡，并降低由 Aβ1-42 蛋白聚集诱导的脂质过氧化水平。Chalcones A-N-5 是一种很有前途的分子骨架候选物，可用于进一步开发用于体内试验的先导化合物以研究 AD。

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Chalcones A-N-5 Chemical Structure

Chalcones A-N-5 Chemical Structure

CAS No. : 2756846-09-8

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Chalcones A-N-5 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Chalcones A-N-5 is a trihydroxy chalcone derivative compound. Chalcones A-N-5 doesn’t show cytotoxicity at the concentration lower than 100 µM (with IC50 > 1 mM), but has a significant effect on promoting cell proliferation. Chalcones A-N-5 potentially promotes neuronal cell growth in the damaged brain tissue. Chalcones A-N-5 also inhibits ferroptosis induced by RSL or erastin and reduces the lipid peroxidation levels induced by Aβ1-42 protein aggregation. Chalcones A-N-5 is a promising molecular skeleton candidate for further development of lead compound for in vivo test to research AD[1].

分子量

392.41

Formula

C21H20N4O4
CAS 号
Unlabeled CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Chalcones A-N-5 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Chalcones A-N-52756846-09-8Ferroptosiscytotoxicityproliferationneuronal cell growthbrain tissueferroptosislipid peroxidationAβ1-42ADInhibitorinhibitorinhibit

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