2. Immunology/Inflammation Stem Cell/Wnt JAK/STAT Signaling
  3. IFNAR STAT
  4. Cirsilineol

Cirsilineol  (Synonyms: 甲基条叶蓟素)

目录号: HY-119347 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

Cirsilineol 是一种天然黄酮化合物，可选择性抑制肠道 CD4+ T 细胞中的 IFN-γ/STAT1/T-bet 信号。Cirsilineol 具有免疫抑制和抗肿瘤特性。Cirsilineol 显着改善三硝基苯磺酸 (TNBS) 诱导的小鼠 T 细胞介导的实验性结肠炎。

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Cirsilineol Chemical Structure

Cirsilineol Chemical Structure

CAS No. : 41365-32-6

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规格 价格 是否有货 数量
1 mg ￥4200
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Cirsilineol 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cirsilineol, a natural flavone compound, selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4+ T cells. Cirsilineol has potent immunosuppressive and anti-tumor properties. Cirsilineol significantly ameliorates trinitro-benzene sulfonic acid (TNBS)-induced T-cell-mediated experimental colitis in mice[1].

体外研究
(In Vitro)

Cirsilineol (0.1-10 μM；96 小时) 以剂量依赖性方式抑制单个混合淋巴细胞反应和 Concanava A 诱导的 T 细胞增殖。Cirsilineol (10 μM) 不影响 T 淋巴细胞的活力。cirsilineol (10 μM) 对 T 细胞增殖的抑制不是由于细胞毒活性[1]。
Cirsilineol (1-10 μM；预处理 3 小时) 完全抑制 IFN-γ 诱导的 Tyr701 磷酸化 STAT1 和 JAK2 激活[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cirsilineol 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Splenocytes
Concentration: 0.1, 1, 10 μM
Incubation Time: 96 hours
Result: Inhibited single mixed lymphocyte reaction and Concanavalin A (Con A; 5 μg/mL; for 72 h)-induced T-cell proliferation in a dose-dependent manner.
Suppressed OVA323-339-specific CD4+ T-cell proliferation.

Western Blot Analysis[1]

Cell Line: Splenic CD4+ T cells
Concentration: 1, 5, 10 μM
Incubation Time: Pretreatment for 3 hours
Result: Completely inhibited IFN-γ-induced (25 ng; 30 mins) Tyr701 phosphorylation of STAT1 and JAK2 activation.
Suppressed IFN-γ-induced (25 ng; 12 hours) Th1-specific transcription factor T-bet.
体内研究
(In Vivo)

cirsilineol (3、10 和 30 mg/kg) 通过抑制 CD4+ T 细胞中的 IFN-γ/STAT1/T-bet 信号显著改善 TNBS 诱导的 Th1 介导的结肠炎。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-10-week-old female C57BL/6, BALB/c and DO11.10 transgenic mice with TNBS (10 mg; 100 μL)[1]
Dosage: 3, 10, 30 mg/kg
Administration: IP; daily; for 11 days
Result: Showed a significant improved effect on the body weights and survival rate of mice.
Markedly reduced inflammatory infiltration, restoration of the destructive mucosal architecture and remission of edema.
分子量

344.32

Formula

C18H16O7
CAS 号
性状

固体

颜色

White to light yellow

中文名称

甲基条叶蓟素
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥98.0%

COA (193 KB)

产品使用指南 (1538 KB)
参考文献

Cirsilineol 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cirsilineol41365-32-6甲基条叶蓟素IFNARSTATInterferon-α/β receptorInterferon-alpha/beta receptorIFN-γSTAT1T-betCD4+T cellsimmunosuppressiveTNBScolitisSplenocytesInhibitorinhibitorinhibit

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目录号：
HY-119347
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