2. Anti-infection
  3. Influenza Virus Parasite
  4. Cletoquine

Cletoquine  (Synonyms: Desethylhydroxychloroquine)

目录号: HY-135810
产品使用指南

摩尔计算器

Cletoquine (Desethylhydroxychloroquine) 是 Hydroxychloroquine 的主要活性代谢产物，是由 CYP2D6，CYP3A4，CYP3A5 和 CYP2C8 同工酶在肝脏中形成的。Cletoquine 也是一种 Chloroquine 衍生物，具有抗基孔肯雅热病毒 (CHIKV) 的能力。Cletoquine 具有抗疟作用，并可用于自身免疫性疾病的研究。

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Cletoquine Chemical Structure

Cletoquine Chemical Structure

CAS No. : 4298-15-1

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规格 价格 是否有货 数量
1 mg ￥4950
In-stock
5 mg   询价  
10 mg   询价  

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Customer Review

Other Forms of Cletoquine:

Cletoquine 相关抗体

Top Publications Citing Use of Products

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].

IC50 & Target

Chikungunya virus (CHIKV)[2]
体内研究
(In Vivo)

Hydroxychloroquine (5 mg/kg intravenously) is administered to BALB/c mice for blood and tissue to determine the content of Cletoquine (Desethylhydroxychloroquine). The tissue to blood concentration ratio (Kp) is ≥1, indicating accumulation of Cletoquine in tissues. The Cletoquine Kp ratio for the various tissues are observed in the descending order of liver (114.3)>kidney (24.4)>spleen (19.3)>lungs (16.5)>heart (5.5)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

307.82

Formula

C16H22ClN3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cletoquine 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cletoquine4298-15-1DesethylhydroxychloroquineInfluenza VirusParasiteHydroxychloroquineNdesethylationCYP2D6CYP3A4CYP3A5CYP2C8antimalarialP23pro-zbdCHIKVantiviralInhibitorinhibitorinhibit

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