2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. CU-CPD107

CU-CPD107 是一种有效的选择性 toll-like receptor (TLR 8) 激动剂。CU-CPD107 抑制 TLR8 信号通路。CU-CPD107 在 ssRNA 存在下转化为协同激动剂活性并诱导 TLR8 信号转导。CU-CPD107 抑制促炎因子表达，避免 ssRNA 存在时产生的免疫反应。

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CU-CPD107 Chemical Structure

CU-CPD107 Chemical Structure

CAS No. : 2573912-32-8

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规格 价格 是否有货
1 mg ￥1042
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CU-CPD107 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

查看所有亚型
TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CU-CPD107 is a potent, selective toll-like receptor 8 (TLR 8) agonist. CU-CPD107 inhibits TLR8 signaling. CU-CPD107 converts to synergistic agonist activities in the presence of ssRNA and induces TLR8 signaling. CU-CPD107 inhibits proinflammatory factor expression and avoids immune responses in the presence of ssRNA[1].

体外研究
(In Vitro)

CU-CPD107 (HEK-Blue hTLR8 cells) inhibits R848-induced signaling with an IC50 value of 13.7 µM[1].
CU-CPD107 (0-100 µM; HEK-Blue hTLR8 cells) converts to an agonist in the presence of ssRNA[1].
CU-CPD107 (100 µM; HEK-Blue hTLR8 cells) decreases IFN-β, TNF-α, IL-1β, IL-6 and IL-8 mRNA expression levels[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CU-CPD107 相关抗体:
分子量

400.25

Formula

C16H21IN2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CU-CPD107 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CU-CPD1072573912-32-8Toll-like Receptor (TLR)TLR8 signalingssRNAsynergistic agonistproinflammatory factorInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-147310
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