2. Immunology/Inflammation Antibody-drug Conjugate/ADC Related
  3. CD38 ADC Antibody
  4. Daratumumab

Daratumumab  (Synonyms: 达雷木单抗; Anti-Human CD38, Human Antibody)

目录号: HY-P9915 纯度: 98.90%
COA

摩尔计算器

Daratumumab (Anti-Human CD38) 是首创的特异性抗 CD38 单克隆抗体 (IgG1)。Daratumumab 具有抗多发性骨髓瘤(MM) 的作用。Daratumumab 损伤了 MM 细胞的粘附，从而增加了 MM 对蛋白酶体抑制的敏感性。

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Daratumumab Chemical Structure

Daratumumab Chemical Structure

CAS No. : 945721-28-8

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规格 价格 是否有货 数量
1 mg ￥1600
In-stock
5 mg ￥5600
In-stock
10 mg ￥8680
In-stock
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Customer Review

Other Forms of Daratumumab:

Daratumumab 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Daratumumab (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition[1][2].

体外研究
(In Vitro)

Daratumumab (Anti-Human CD38) induces potent Ab-dependent cellular cytotoxicity in CD38-expressing lymphoma- and MM-derived cell lines[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Daratumumab 相关抗体:
体内研究
(In Vivo)

Daratumumab (i.p.; 0.5 mg/kg; 14 d after challenge with Daudi-luc cells) inhibits outgrowth of CD38-expressing tumor cells in mouse xenograft tumor models[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8- to 10-wk-old C.B-17 SCID mice (luciferase-expressing Daudi cells)[2]
Dosage: 0.5 mg/kg
Administration: I.p.; 14 day after challenge with Daudi-luc cells
Result: Effectively inhibited tumor growth compared with control-treated animals in which tumor grew rapidly and therefore required euthanasia on day 35. On day 28 and day 35, tumor size in Daratumumab-treated animals was significantly different from the control.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

达雷妥尤单抗； 达妥木单抗
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 98.90%

COA (172 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Daratumumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Daratumumab945721-28-8Anti-Human CD38, Human Antibody达雷妥尤单抗 达妥木单抗CD38ADC AntibodymyelomacelladhesioncytotoxicitytumorMMNKantibodyInhibitorinhibitorinhibit

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