1. Cell Cycle/DNA Damage Antibody-drug Conjugate/ADC Related Autophagy Anti-infection Apoptosis
  2. Topoisomerase DNA/RNA Synthesis ADC Cytotoxin Autophagy Bacterial Antibiotic Apoptosis
  3. Daunorubicin

Daunorubicin  (Synonyms: 柔红霉素; Daunomycin; RP 13057; Rubidomycin)

目录号: HY-13062A
产品使用指南

Daunorubicin (Daunomycin) 是一种拓扑异构酶 II (topoisomerase II) 抑制剂,具有有效的抗肿瘤活性。Daunorubicin 抑制 DNA 和 RNA 合成 (DNA and RNA synthesis)。Daunorubicin 是一种细胞毒素,可抑制癌细胞活力并诱导细胞凋亡 (apoptosis) 和坏死 (necrosis)。Daunorubicin 还是一种蒽环类抗生素。Daunorubicin 可用于研究感染和多种癌症,包括白血病、非霍奇金淋巴瘤、尤文氏肉瘤、维尔姆斯氏瘤。

在相同的摩尔浓度下,化合物盐形式与游离形式有相同的生物活性,但盐形式 Daunorubicin hydrochloride 通常具有更好的水溶性和稳定性。

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Daunorubicin Chemical Structure

Daunorubicin Chemical Structure

CAS No. : 20830-81-3

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor[1][2][4][5].

IC50 & Target[1][2]

Topoisomerase II

 

Daunorubicins/Doxorubicins

 

体外研究
(In Vitro)

Daunorubicin (0-256 μg/mL, 30 min) inhibits DNA and RNA synthesis in sensitive and resistant Ehrlich ascites tumor cells[2].
Daunorubicin (7 nM-1.9 μM, 72 h) shows chemosensitivity in Molt-4 cells and L3.6 cells[3][4].
Daunorubicin (0.4 μM, 48 h) induces apoptotic and necrosis in L3.6 cells[4].
Daunorubicin (0.4 μM, 120 min) induces ROS generation in L3.6 cells[4].
Daunorubicin (2 μM, 24 h) induces autophagy in K562 cells (myeloid cell line)[6].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3][4]

Cell Line: Molt-4 cells (a human T-lymphoblastic leukemia cell line), L3.6 cells (metastatic human pancreatic cell line)
Concentration: 7 nM-1.9 μM
Incubation Time: 72 h
Result: Inhibited cell viability with IC50 values of 40 nM (Molt-4) and 400 nM (L3.6).

Apoptosis Analysis[4]

Cell Line: L3.6 cells
Concentration: 0.4 μM
Incubation Time: 24 h, 48 h
Result: Induced necrosis without apoptosis at 24 h, induced both an apoptotic and extensive necrotic response at 48 h.

Western Blot Analysis[6]

Cell Line: K562 cells
Concentration: 2 μM
Incubation Time: 24 h
Result: Enabled the switch of LC3-I into LC3-II, accompanied with a significant increased expression level of LC3.
体内研究
(In Vivo)

Daunorubicin (intravenous injection, 3 mg/kg, three times at 48 h intervals.) produces cardiotoxicity and nephrotoxicity in rats[5].
Daunorubicin (intraperitoneal injection, 10 mg/kg) induces sister chromatid exchanges in mice[7].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[5]
Dosage: 3 mg/kg
Administration: Intravenous injection, three times at 48 h intervals.
Result: Caused a significant increase in MDA (malondialdehyde) level in renal tissue, accompanied by a significant reduction in total GPx activity.
Increased urinary protein excretion, serum creatinine, and BUN level.
Clinical Trial
分子量

527.52

Formula

C27H29NO10

CAS 号
中文名称

柔红霉素;红保霉素;红比霉素;红卫霉素;柔毛霉素;正定霉素;道诺霉素

结构分类
初始来源

Streptomyces peucetius and S. peucetius subsp. caesius

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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