2. Epigenetics
  3. Histone Methyltransferase
  4. DDO-2093 dihydrochloride

DDO-2093 dihydrochloride 

目录号: HY-132233A 纯度: 98.52%
COA 产品使用指南

摩尔计算器

DDO-2093 dihydrochloride 是一种有效的 MLL1 和 WDR5 蛋白-蛋白相互作用抑制剂 (IC50=8.6 nM; Kd=11.6 nM)，具有抗肿瘤活性。DDO-2093 dihydrochloride 选择性抑制 MLL 复合物的催化活性。

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DDO-2093 dihydrochloride Chemical Structure

DDO-2093 dihydrochloride Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥2320
In-stock
5 mg ￥5800
In-stock
10 mg ￥8990
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of DDO-2093 dihydrochloride:

DDO-2093 dihydrochloride 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DDO-2093 dihydrochloride is a potent MLL1-WDR5 protein-protein interaction inhibitor (IC50=8.6 nM; Kd=11.6 nM) with antitumor activity. DDO-2093 dihydrochloride selectively inhibits the catalytic activity of MLL complex[1].

体外研究
(In Vitro)

DDO-2093 (5 μM; pretreated 7 days) dihydrochloride inhibits MLL-fusion protein dependent genes expression (HOXA9 and Meis1)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DDO-2093 dihydrochloride 相关抗体:

Western Blot Analysis[1]

Cell Line: MV4-11 cells
Concentration: 1, 2.5, 5, and 10 μM
Incubation Time: 7 days
Result: Dose-dependently reduced the mono-, di-, and trimethylation of H3K4.
体内研究
(In Vivo)

DDO-2093 (20-80 mg/kg; i.p.; every other day for 21 days) dihydrochloride significantly suppresses the tumor size and weight in a dose-dependent manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nude mice (MV4-11 human leukemia cancer xenografts)[1]
Dosage: 20, 40, and 80 mg/kg
Administration: Intraperitoneal injection; every other day for 21 days
Result: Had the tumor volume growth inhibition (GI) values were calculated to be 13.7%, 37.6% and 63.9% with doses of 20 mg/kg, 40 mg/kg and 80 mg/kg, respectively.
分子量

687.04

Formula

C29H39Cl3FN9O3
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (145.55 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.4555 mL 7.2776 mL 14.5552 mL
5 mM 0.2911 mL 1.4555 mL 2.9110 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

DDO-2093 dihydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4555 mL 7.2776 mL 14.5552 mL 36.3880 mL
5 mM 0.2911 mL 1.4555 mL 2.9110 mL 7.2776 mL
10 mM 0.1456 mL 0.7278 mL 1.4555 mL 3.6388 mL
15 mM 0.0970 mL 0.4852 mL 0.9703 mL 2.4259 mL
20 mM 0.0728 mL 0.3639 mL 0.7278 mL 1.8194 mL
25 mM 0.0582 mL 0.2911 mL 0.5822 mL 1.4555 mL
30 mM 0.0485 mL 0.2426 mL 0.4852 mL 1.2129 mL
40 mM 0.0364 mL 0.1819 mL 0.3639 mL 0.9097 mL
50 mM 0.0291 mL 0.1456 mL 0.2911 mL 0.7278 mL
60 mM 0.0243 mL 0.1213 mL 0.2426 mL 0.6065 mL
80 mM 0.0182 mL 0.0910 mL 0.1819 mL 0.4548 mL
100 mM 0.0146 mL 0.0728 mL 0.1456 mL 0.3639 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DDO-2093DDO2093DDO 2093Histone MethyltransferaseMLL1WDR5antitumorcatalyticcomplexMV4-11leukemiacancerInhibitorinhibitorinhibit

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产品名称：
DDO-2093 dihydrochloride
目录号：
HY-132233A
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