2. Cell Cycle/DNA Damage Epigenetics Apoptosis Metabolic Enzyme/Protease
  3. HDAC Apoptosis Drug Metabolite
  4. DL-Sulforaphane N-acetyl-L-cysteine

DL-Sulforaphane N-acetyl-L-cysteine  (Synonyms: SFN-NAC)

目录号: HY-132242
产品使用指南

摩尔计算器

DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC) 是一种具有口服活性的 HDAC 抑制剂，也是sulforaphane (HY-13755) 代谢物且具有更长的半衰期和更好的血脑屏障通透性。DL-Sulforaphane N-acetyl-L-cysteine 通过 ERK 途径激活自噬介导的 α-微管蛋白表达下调，可用于癌症的研究。

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DL-Sulforaphane N-acetyl-L-cysteine Chemical Structure

DL-Sulforaphane N-acetyl-L-cysteine Chemical Structure

CAS No. : 334829-66-2

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规格 价格 是否有货 数量
1 mg ￥990
3 - 4 周
5 mg ￥4140
3 - 4 周
10 mg   询价  
50 mg   询价  

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DL-Sulforaphane N-acetyl-L-cysteine 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC) is an orally active HDAC inhibitor and metabolite of sulforaphane (HY-13755) with longer half-life and better blood-brain barrier permeability. DL-Sulforaphane N-acetyl-L-cysteine activates autophagy-mediated downregulation of α-tubulin expression through the ERK pathway and can be used in cancer research[1][2].

体外研究
(In Vitro)

SFN-NAC (24 h) 会降低细胞活力，HA 细胞，U87MG 细胞，U373MG 细胞和 U87/TR 细胞的 IC50 值分别为 60.08 μM，35.20 μM，39.11 μM，36.20 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DL-Sulforaphane N-acetyl-L-cysteine 相关抗体:

Cell Cycle Analysis[1]

Cell Line: U87MG and U373MG cells
Concentration: 0, 30 μM
Incubation Time: 24 h
Result: Induced cell-cycle arrest in the G2/M phase and triggered apoptosis at the same time.

Western Blot Analysis[1]

Cell Line: U87MG and U373MG cells
Concentration: 0, 10, 20, 30, 40, 50μM
Incubation Time: 24 h
Result: Activated ERK1/2 (Thr202/Tyr204), downregulated α-tubulin, and induced autophagy in a dose-dependent manner.

Cell Viability Assay[1]

Cell Line: HA, U87MG, U373MG and U87/TR cells
Concentration: 0, 10, 20, 30, 40, 50, 60, 70, 80, 90 μM for HA and U87MG cells or 0, 10, 20, 30, 40, 50, 60 μM for U373MG and U87/TR cells
Incubation Time: 24 h
Result: Decreased the cell viability of these cell lines in a dose-dependent manner.
体内研究
(In Vivo)

SFN-NAC (10 μmol; 6 h; Oral gavage; single dose) 显着抑制小鼠结肠粘膜中的 HDAC 活性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: mice[2]
Dosage: 10 μmol
Administration: Oral gavage; 6 h; single dose
Result: Significantly inhibited HDAC activity in mouse colon mucosa.
分子量

340.48

Formula

C11H20N2O4S3
CAS 号
Unlabeled CAS

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

DL-Sulforaphane N-acetyl-L-cysteine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DL-Sulforaphane N-acetyl-L-cysteine334829-66-2SFN-NACHDACApoptosisDrug MetaboliteHistone deacetylasesGliomaAutophagySulforaphaneα-tubulinEpigeneticsEpigenomicsChromatin remodelingAcetylated histonesCancer preventionDietButyrateOrganosulfur compoundsGarlicCruciferous vegetablesInhibitorinhibitorinhibit

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