1. Anti-infection
  2. Bacterial Antibiotic
  3. Doripenem

Doripenem  (Synonyms: 多尼培南; S 4661)

目录号: HY-B0187
产品使用指南

Doripenem (S 4661) 是一种 1β-甲基肠外碳青霉烯类药物,对革兰氏阳性和革兰氏阴性需氧菌具有非常广谱的活性。

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Doripenem Chemical Structure

Doripenem Chemical Structure

CAS No. : 148016-81-3

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Other Forms of Doripenem:

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Doripenem (S 4661), a 1β-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria[1][2].

IC50 & Target

β-lactam

 

体内研究
(In Vivo)

Doripenem (S 4661;MIC 范围为 2 至 16 μg/ml;皮下注射;1 小时和 4 小时输注;0.2 ml 注射) 显示出对铜绿假单胞菌的抗菌作用[1]
Doripenem (10、50、150 mg/kg;0.2 ml 体积;皮下注射 2 小时) 在 10 mg/kg 剂量对小鼠的 T1/2 为 0.41 小时,CL 为 673.9 mL/h•kg[1]
Pharmacokinetic Parameters of Doripenem in mice[1].

SC (10 mg/kg) SC (50 mg/kg) SC (150 mg/kg)
Tmax (h) 0.25 0.38 0.22
Cmax (μg/mL) 16.3 59.7 194.4
AUC0-24 (ng∗h /mL) 13.5 62.4 168
t1/2 (h) 0.41 0.34 0.44
CL (mL/h/kg) 673.9 783.3 850.5
V (mL/kg) 400.7 384.7 545.8

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Specific-pathogen-free, female ICR mice weighing approximately 25 g with P. aeruginosa-infected thighs[1]
Dosage: MIC range of 2 to 16 μg/ml
Administration: Subcutaneous; 1-h and 4-h infusion; 0.2 ml injections
Result: Demonstrated antibacterial killing for P. aeruginosa.
Clinical Trial
分子量

420.50

Formula

C15H24N4O6S2

CAS 号
中文名称

多尼培南

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Doripenem 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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