1. Inhibitory Antibodies
  2. Empasiprubart

Empasiprubart  (Synonyms: ARGX-117)

目录号: HY-P990025 纯度: 97.93%
COA

Empasiprubart (ARGX-117) 是一种针对补体 C2 的人源化抑制性单克隆抗体。Empasiprubart 通过与 C2 的 Sushi-2 结构域结合,防止 C3 原转化酶的形成,并抑制 C3 激活上游的经典途径和凝集素途径激活。Empasiprubart 表现出 pH 和钙依赖性靶标结合。Empasiprubart 在自身免疫性溶血性贫血和抗体介导的器官移植排斥的体外模型中预防补体介导的细胞毒性。

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Empasiprubart Chemical Structure

Empasiprubart Chemical Structure

CAS No. : 2579031-19-7

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Empasiprubart (ARGX-117) a humanized inhibitory monoclonal antibody against complement C2. Empasiprubart prevents the formation of the C3 proconvertase and inhibits classical and lectin pathway activation upstream of C3 activation through binding to the Sushi-2 domain of C2. Empasiprubart exhibits pH- and calcium-dependent target binding. Empasiprubart prevents complement-mediated cytotoxicity in in vitro models for autoimmune hemolytic anemia and antibody-mediated rejection of organ transplants[1].

同型

Human IgG1 kappa

推荐同型对照抗体
种属

Humanized

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

纯度: 97.93%

参考文献
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产品名称:
Empasiprubart
目录号:
HY-P990025
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