2. Metabolic Enzyme/Protease
  3. Renin
  4. Enalkiren

Enalkiren  (Synonyms: A-64662)

目录号: HY-105276
产品使用指南

摩尔计算器

Enalkiren (A-64662) 是一种有效的双肽肾素 (dipeptide renin) 抑制剂，在纯化的肾素-血管紧张素原系统中 (pH=6.0)，IC50 为 0.78 nM。Enalkiren 抑制肾素活性，也降低收缩压和舒张压。Enalkiren 可用于原发性高血压的研究。

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Enalkiren Chemical Structure

Enalkiren Chemical Structure

CAS No. : 113082-98-7

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Enalkiren 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Enalkiren (A-64662) is a potent dipeptide renin inhibitor with an IC50 of 0.78 nM in a purified renal renin-angiotensinogen system (pH=6.0). Enalkiren suppresses renin activity, and also reduces systolic and diastolic blood pressure. Enalkiren can be used to research essential hypertension[1][2].

IC50 & Target

IC50: 23 nM (hamster dipeptide renin), 14 nM (human dipeptide renin), 2.3 nM (cynomolgus monkey dipeptide renin)[2]
体外研究
(In Vitro)

Enalkiren inhibits the endogenous renin-angiotensinogen reaction with an IC50 value of 23 nM, 14 nM and 2.3 nM in hamster, human and cynomolgus monkey plasma, respectively, at pH 7.4[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Enalkiren 相关抗体:
体内研究
(In Vivo)

Enalkiren (0.01-10 mg/kg; i.v.; single dosage) reduces mean arterial blood pressure in cynomolgus monkey[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkey[2]
Dosage: 0.01-10 mg/kg
Administration: i.v.; single dosage
Result: Reduced mean arterial blood pressure in a dose-related manner.
分子量

656.86

Formula

C35H56N6O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Enalkiren 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Enalkiren113082-98-7A-64662A64662A 64662Reninessential hypertensionarterialblood pressurecynomolgus monkeyhamsterrenin-angiotensinogenInhibitorinhibitorinhibit

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