2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Ent-(+)-Verticilide

ent-(+)-verticilide 是一种具有抗心律失常活性的强效和选择性的心脏 ryanodine 受体 (RyR2) 钙释放通道抑制剂。ent-(+)-verticilide 抑制 ryr2 介导的舒张 Ca2+ 渗漏，与丹曲林和丁卡因相比，具有更高的效价和独特的作用机制。ent-(+)-verticilide 是研究针对 RyR2 过度活跃在心脑病理中的治疗潜力的有用工具。

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Ent-(+)-Verticilide Chemical Structure

Ent-(+)-Verticilide Chemical Structure

CAS No. : 2056011-05-1

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Other Forms of Ent-(+)-Verticilide:

Ent-(+)-Verticilide 相关抗体

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  • 生物活性

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生物活性

ent-(+)-verticilide is a potent and selective inhibitor of cardiac ryanodine receptor (RyR2) calcium release channels with antiarrhythmic activity. ent-(+)-verticilide inhibits RyR2-mediated diastolic Ca2+?leak and exhibits higher potency and a distinct mechanism of action compared with theDantrolene and Tetracaine.?ent-(+)-verticilide is a useful tool to investigate the therapeutic potential of targeting RyR2 hyperactivity in heart and brain pathologies[1].

分子量

853.09

Formula

C44H76N4O12
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ent-(+)-Verticilide 相关分类

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Keywords:

Ent-(+)-Verticilide2056011-05-1 Calcium ChannelCa2+ channelsCa channelsnatural productryanodine receptorCPVTcardiomyocytesdepsipeptideInhibitorinhibitorinhibit

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