2. Cell Cycle/DNA Damage Apoptosis
  3. Topoisomerase Apoptosis
  4. erythro-Austrobailignan-6

erythro-Austrobailignan-6 是一种具有口服活性的抗癌剂。erythro-Austrobailignan-6 抑制 DNA 拓扑异构酶 (topoisomerase) I 和 II 活性。erythro-Austrobailignan-6 诱导细胞凋亡 (apoptosis) 并增加 p38 和 JNK 的磷酸化。

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erythro-Austrobailignan-6 Chemical Structure

erythro-Austrobailignan-6 Chemical Structure

CAS No. : 114127-24-1

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erythro-Austrobailignan-6 相关抗体

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Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

erythro-Austrobailignan-6 is an orally active anti-cancer agent. erythro-Austrobailignan-6 inhibits DNA topoisomerase I and II activity. erythro-Austrobailignan-6 induces cell apoptosis and increases phosphorylation of p38 and JNK[1][2].

体外研究
(In Vitro)

erythro-Austrobailignan-6 (100 μM) 抑制 DNA 拓扑异构酶 I 活性超过 50%[1]。
erythro-Austrobailignan-6 (0-30 μM, 24 或 48 h) 抑制 4T-1 细胞和 MCF-7 细胞的增殖[1].
erythro-Austrobailignan-6 (2-30 μM，24 或 48 小时) 诱导 4T-1 和 MCF-7 细胞凋亡[1]。
erythro-Austrobailignan-6 (10 μM，30-120 分钟) 增加4T-1 和 MCF-7 细胞 p38 和 JNK 的磷酸化水平[1]。
erythro-Austrobailignan-6 (5 和 10 μM，24 小时) 降低 4T-1 和 MCF-7 细胞中的 EGFR/HER2 和拓扑异构酶水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

erythro-Austrobailignan-6 相关抗体:

Cell Viability Assay[1]

Cell Line: 4T-1 and MCF-7 cells
Concentration: 0-30 μM
Incubation Time: 24 or 48 h
Result: Dose dependently inhibited cell proliferation.

Western Blot Analysis[1]

Cell Line: 4T-1 and MCF-7 cells
Concentration: 100 μM
Incubation Time: 30, 60 or 120 min
Result: Increased phosphorylation of p38 and JNK.
Activated caspase-3 and inhibited CDK-4 and cyclin D1.
体内研究
(In Vivo)

erythro-Austrobailignan-6 (食物摄取，持续 20 天) 抑制 4T-1 荷瘤小鼠的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4T-1 tumor bearing mice[1]
Dosage: 20 mg/kg/day
Administration: Food intake
Result: Inhibited tumor growth by 40.8%;
Down-regulated CDK-4, cyclin D1, HER2 and integrin β3;
Up-regulated cleaved caspase-3 in tumor.
分子量

328.40

Formula

C20H24O4
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

erythro-Austrobailignan-6 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

erythro-Austrobailignan-6114127-24-1TopoisomeraseApoptosisCancer4T-1MCF-7p38JNKInhibitorinhibitorinhibit

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erythro-Austrobailignan-6
目录号：
HY-N11536
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