2. Metabolic Enzyme/Protease Neuronal Signaling
  3. FAAH
  4. FAAH-IN-7

FAAH-IN-7 是一种可逆且有效的 FAAH 抑制剂，IC50 为 8.29 nM。FAAH-IN-7 能够抑制 1321N1星形胶质细胞氧化应激，在离体神经炎症模型中表现出显著的神经保护作用。

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FAAH-IN-7 Chemical Structure

FAAH-IN-7 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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FAAH-IN-7 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FAAH-IN-7 is a reversible and potent FAAH inhibitor with an IC50 value of 8.29 nM. FAAH-IN-7 suppresses oxidative stress in 1321N1 astrocytes and exhibits notable neuroprotective effect in ex vivo neuroinflammation model[1].

体外研究
(In Vitro)

FAAH-IN-7 (化合物 4e) (10 nM-30 μM; 24 h) 小鼠成纤维细胞NIH3T3和人星形胶质细胞1321N1无细胞毒性，且对Ki值为>10 μM的[1]。
FAAH-IN-7 (10 nM, 100 nM; 30 min) 通过可逆机制抑制 FAAH。快速稀释破坏了抑制剂和酶之间的平衡，导致酶活性恢复[1]。
FAAH-IN-7 (1 nM-1 μM; 24 h) 在 1321N1 星形胶质细胞中，从 10 nM 开始显著减少活性氧 (ROS) 的产生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FAAH-IN-7 相关抗体:

Cell Viability Assay[1]

Cell Line: 1321N1 human astrocytes
Concentration: 10 nM, 100 nM, 1 μM, 10 μM, and 30 μM
Incubation Time: 24 hours
Result: Showed no cytotoxicity against 1321N1 human astrocytes.
体内研究
(In Vivo)

FAAH-IN-7 (化合物 4e) 在大鼠海马外植体炎症诱导的神经退变体外培养中显示抗炎作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

447.53

Formula

C26H29N3O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FAAH-IN-7 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FAAH-IN-7FAAHFatty acid amide hydrolaseInhibitorinhibitorinhibit

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目录号：
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