2. Anti-infection
  3. Antibiotic
  4. Farletuzumab

Farletuzumab  (Synonyms: MORAb-003)

目录号: HY-P99153 纯度: 99.00%
COA

摩尔计算器

Farletuzumab (MORAb-003) 是一种有效的叶酸受体-α (FRα) 抑制剂。Farletuzumab 是一种人源化单克隆抗体，对 FRα 具有高亲和力。Farletuzumab 对过表达 FRα 的细胞具有生长抑制作用。Farletuzumab 可用于癌症研究。

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Farletuzumab Chemical Structure

Farletuzumab Chemical Structure

CAS No. : 896723-44-7

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规格 价格 是否有货 数量
1 mg ￥3500
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Farletuzumab 相关抗体

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Farletuzumab (MORAb-003) is a potent folate receptor-alpha (FRα) inhibitor. Farletuzumab is a humanized monoclonal antibody with high affinity for FRα. Farletuzumab possesses growth-inhibitory functions on cells overexpressing FRα. Farletuzumab can be used in research of cancer[1].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Humanized
体外研究
(In Vitro)

Farletuzumab (MORAb-003; 0-10 µg/mL; CHO-FR cells) inhibits FRα-dependent cell growth and increases folate EC50 in a dose-dependent manner[1].
Farletuzumab (0.1-100 µg/mL; IGROV-1 cells; 1 h) mediates tumor cytotoxicity via complement dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC) in vitro[1].
Farletuzumab (0-10 µg/mL; CHO-FR cells) inhibits phosphorylation of proteins by Lyn kinase, a member of the src family of kinases, thereby, blocking a FRa-mediated signaling pathway[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Farletuzumab 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: IGROV-1 cells
Concentration: 0.1, 1, 10, and 100 µg/mL
Incubation Time: 1 hours
Result: Had significant cytotoxicity at IGROV-1 cells.
Clinical Trial
分子量

145360.00

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 99.00%

COA (173 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Farletuzumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Farletuzumab896723-44-7MORAb-003MORAb003MORAb 003Antibiotichumanized monoclonal antibodyfolate receptor-alphaanticancerCHO-FR cellsIGROV-1 cellsInhibitorinhibitorinhibit

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