2. Apoptosis Immunology/Inflammation Autophagy Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. FKBP HSP
  4. FKBP51-Hsp90-IN-2

FKBP51-Hsp90-IN-2 (化合物 E08) 是一种选择性 FKBP51-Hsp90 蛋白-蛋白相互作用抑制剂，其对FKBP51 和 FKBP52 的 IC50 值分别为 0.4 µM 和 5 µM。FKBP51-Hsp90-IN-2 还可有效刺激细胞能量代谢和神经突生长。FKBP51-Hsp90-IN-2 可用于神经退行性疾病和癌症的研究。

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FKBP51-Hsp90-IN-2 Chemical Structure

FKBP51-Hsp90-IN-2 Chemical Structure

CAS No. : 601511-07-3

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FKBP51-Hsp90-IN-2 相关抗体

Top Publications Citing Use of Products

查看 HSP 亚型特异性产品:

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

FKBP51-Hsp90-IN-2 (Compound E08) is a selective FKBP51-Hsp90 protein-protein interaction inhibitor with IC50 values of 0.4 µM and 5 µM for FKBP51 and FKBP52, respectively. FKBP51-Hsp90-IN-2 also effectively stimulates cellular energy metabolism and neurite growth. FKBP51-Hsp90-IN-2 can be used in research on neurodegenerative diseases and cancer[1].

IC50 & Target

IC50: 0.4 µM (FKBP51); 5 µM (FKBP52)[1].
体外研究
(In Vitro)

FKBP51-Hsp90-IN-2 (3-30 μM; 48 h) 在 HEK293 细胞中抑制 Hsp90 与 FKBP51 的结合[1]。
FKBP51-Hsp90-IN-2 (10 μM; 1-4 h) 增加 HEK293 细胞能量代谢[1]。
FKBP51-Hsp90-IN-2 刺激分化神经母细胞瘤 SH-SY5Y 细胞中的神经突生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

FKBP51-Hsp90-IN-2 相关抗体:

Cell Viability Assay[1]

Cell Line: HEK293 cells
Concentration: 10 μM
Incubation Time: 1, 2, 4 h
Result: Increased cell viability measured by MTT assay by 10-25%.

Western Blot Analysis[1]

Cell Line: HEK293 cells
Concentration: 3, 10, 30 μM
Incubation Time: 48 h
Result: Inhibited FKBP51-Hsp90 protein-protein interaction.
分子量

433.57

Formula

C25H27N3O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

FKBP51-Hsp90-IN-2 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FKBP51-Hsp90-IN-2601511-07-3FKBPHSPFK506-binding proteinHeat shock proteinsHEK293SH-SY5Yneuritecancertumorneurodegenerative diseasesInhibitorinhibitorinhibit

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