2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. Fusarochromanone

Fusarochromanone  (Synonyms: FC-101)

目录号: HY-136901
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摩尔计算器

Fusarochromanone (FC-101) 是一种真菌代谢物，具有有效的抗血管生成和抗癌活性。Fusarochromanone 激活的 JNK 通路归因于活性氧 (ROS) 的诱导。

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Fusarochromanone Chemical Structure

Fusarochromanone Chemical Structure

CAS No. : 802915-53-3

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Fusarochromanone 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Fusarochromanone (FC-101) is a fungal metabolite with potent anti-angiogenic and anti-cancer activity[1]. Fusarochromanone-activated JNK pathway is attributed to induction of reactive oxygen species (ROS)[2].

体外研究
(In Vitro)

Fusarochromanone (FC101; 10 μM; 24 hours) induces apoptosis and an increase in proportion of cells in the sub-G1 phase in both HaCat and P9-WT cell lines[1].
Fusarochromanone (FC101; 0-1 μM; 24 h) induces the cleavage of both caspase-3 and PARP, a well-known substrate for activated caspases. FC101 does not affect the expression of the anti-apoptotic proteins, Bcl-2, Bcl-XL, Mcl-1, or the pro-apoptotic proteins BAD, BAK, BAX[1].
Fusarochromanone (FC101) exhibits very potent in-vitro growth inhibitory effects (IC50 ranging from 10 nM-2.5 μM) against HaCat (pre-malignant skin), P9-WT (malignant skin), MCF-7 (low malignant breast), MDA-231 (malignant breast), SV-HUC (premalignant bladder), UM-UC14 (malignant bladder), and PC3 (malignant prostate) in a time-course and dose-dependent manner, with the UM-UC14 cells being the most sensitive.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Fusarochromanone 相关抗体:

Cell Cycle Analysis[1]

Cell Line: HaCat and P9-WT cell lines
Concentration: 10 μM
Incubation Time: 24 hours
Result: Showed cells in the G2 and M phases of the cell cycle for both cell lines.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 0.05 μM, 0.1 μM, 0.2 μM, 0.5 μM, 1 μM
Incubation Time: 24 hours
Result: Induced the cleavage of both caspase-3 and PARP.
体内研究
(In Vivo)

Fusarochromanone (8 mg/kg; IP; 5 days per week; for 3.5 weeks) Is well tolerated, non-toxic, and achieved a 30% reduction in tumor size at a dose of 8 mg/kg/day[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID Beige mice (CB17/Icr.Cg-PrkdcscidLystbg/Crl) injected with SRB12-p9 cells[1]
Dosage: 8 mg/kg
Administration: IP; 5 days per week; for 3.5 weeks
Result: Achieved a 30% reduction in tumor size at a dose of 8 mg/kg/day.
分子量

292.33

Formula

C15H20N2O4
CAS 号
结构分类
初始来源

Fusarium equiseti
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Fusarochromanone 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Fusarochromanone802915-53-3FC-101FC101FC 101Reactive Oxygen Speciesfungal metaboliteanti-angiogenicanti-cancer activitycell cycle arrestInhibitorinhibitorinhibit

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