Adam8 - a disintegrin and metallopeptidase domain 8 Gene

中文名称：解整合素和金属肽酶结构域 8

种属: Mus musculus

同用名: MS2; CD156; ADAM 8; CD156a; E430039A18Rik

关于 Adam8

功能概要

该基因编码包含解离蛋白和金属蛋白酶结构域的 Adam 蛋白家族成员。编码的蛋白质位于细胞表面，参与细胞外基质的重塑和细胞迁移。缺乏编码蛋白的小鼠在用过敏原治疗后会出现持续性炎症。该基因的可变剪接导致多个变体。 [RefSeq 提供，2015 年 3 月]

This gene encodes a member of the Adam family of proteins that contain the disintegrin and metalloprotease domains. The encoded protein is localized to the cell surface, where it is involved in the remodeling of extracellular matrix and cell migration. Mice lacking the encoded protein display persistent inflammation upon treatment with allergens. Alternative splicing of this gene results in multiple variants. [provided by RefSeq, Mar 2015]