2. Gene
  3. PLD4 - phospholipase D family member 4 Gene

PLD4 - phospholipase D family member 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷脂酶 D 家族成员 4

种属: Homo sapiens

同用名: C14orf175

基因 ID: 122618 | 基因类型: protein coding

关于 PLD4

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:104,924,879-104,937,785 (from NCBI)

This gene has 7 transcripts (splice variants), 193 orthologues and 2 paralogues. Biased expression in skin (RPKM 31.7), spleen (RPKM 4.6) and 9 other tissues.

功能概要

预计可启用单链 DNA 5'-3' 脱氧核糖核酸酶活性。预计参与造血祖细胞分化；吞噬作用;和调节参与炎症反应的细胞因子的产生。预测定位于早期内体和内质网膜。预计在几种细胞成分中具有活性，包括内质网；吞噬泡;和跨高尔基网络膜。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable single-stranded DNA 5'-3' exodeoxyribonuclease activity. Predicted to be involved in hematopoietic progenitor cell differentiation; phagocytosis; and regulation of cytokine production involved in inflammatory response. Predicted to be located in early endosome and endoplasmic reticulum membrane. Predicted to be active in several cellular components, including endoplasmic reticulum; phagocytic vesicle; and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Apr 2022]

PLD4 基因产物(2)

mRNA Protein Name
NM_001308174.2 NP_001295103.1 5'-3' exonuclease PLD4 isoform 1
NM_138790.5 NP_620145.2 5'-3' exonuclease PLD4 isoform 2

PLD4 蛋白结构

PLDc_3

PLDc_3: PLD-like domain (236 - 414)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 506 a.a.
蛋白主名 其他名称

5'-3' exonuclease PLD4

PLD 4

重组 PLD4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P78019 PLD4 Protein, Human (HEK293, His) Q96BZ4 (W52-G506) ≥95%
HY-P78019A PLD4 Protein, Human (HEK293, C-His) Q96BZ4 (W52-G506) ≥95%

关联疾病

疾病名称 别名
Paraurethral Gland Cancer

Malignant Tumor Of Paraurethral Gland

Malignant Tumor Of The Paraurethral Gland

Skene Gland Carcinoma

Carcinoma Of The Paraurethral Gland

Paraurethral Gland Carcinoma
Nephrotic Syndrome, Type 7

Immunoglobulin-Mediated Membranoproliferative Glomerulonephritis

Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 7

NPHS7

Nephrotic Syndrome Type 7

Ig-Mediated Membranoproliferative Glomerulonephritis

Ig-Mediated Mpgn

Immunoglobulin-Mediated Mpgn

Nephrotic Syndrome, Type 7, With Membranoproliferative Glomerulonephritis

Hemolytic Uremic Syndrome, Atypical 7

Nephrotic Syndrome Type 7 With Membranoptoliferative Glomerulonephritis

Hemolytic Uremic Syndrome With Dgke Deficiency

Hus With Dgke Deficiency

Hemolytic Uremic Syndrome Atypical 7

AHUS7

Nephrotic Syndrome 7

Nephrotic Syndrome Type 7 With Membranoproliferative Glomerulonephritis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10673 PLD4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PLD4 VGNC VGNC:32998
Mus musculus PLD4 MGD MGI:2144765
Macaca mulatta PLD4 VGNC VGNC:76100
Rattus norvegicus PLD4 RGD RGD:1598308
Felis catus PLD4 VGNC VGNC:64214
Canis familiaris PLD4 VGNC VGNC:44663
Others PLD4 NCBI
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