2. Gene
  3. Cxcr2 - chemokine (C-X-C motif) receptor 2 Gene

Cxcr2 - chemokine (C-X-C motif) receptor 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：趋化因子 (CXC 基序) 受体 2

种属: Mus musculus

同用名: CD128; IL8RA; Il8rb; CDw128; Cmkar2; Gpcr16; IL-8Rh; IL-8rb; mIL-8RH

基因 ID: 12765 | 基因类型: protein coding

关于 Cxcr2

Chromosome 1: 74,193,148-74,200,405 forward strand.GRCm39:CM000994.3

This gene has 2 transcripts (splice variants), 244 orthologues, 25 paralogues and is associated with 127 phenotypes. Biased expression in placenta adult (RPKM 4.1), spleen adult (RPKM 3.8) and 8 other tissues.

功能概要

该基因编码的蛋白可启动趋化因子受体活性。在细胞凋亡过程的负调节上游或负调节中起作用。预计位于多个细胞成分中，包括细胞表面；肥大细胞颗粒；和有丝分裂纺锤体。预计在质膜外侧活跃。以多种结构表达，包括消化系统；中枢神经系统;胚胎间充质；上皮;和心。与 IgA 肾小球肾炎有关的该基因的人类直系同源物；急性肾盂肾炎;晚期肾脏疾病;和膀胱癌。与人 CXCR2（CXC 基序趋化因子受体 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Chemokine Receptor activity. Acts upstream of or within negative regulation of apoptotic process. Predicted to be located in several cellular components, including cell surface; mast cell granule; and mitotic spindle. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; epithelium; and heart. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; acute pyelonephritis; end stage renal disease; and urinary bladder Cancer. Orthologous to human CXCR2 (C-X-C motif Chemokine Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Cxcr2 基因产物(1)

mRNA Protein Name
NM_009909.3 NP_034039.1 C-X-C chemokine receptor type 2

Cxcr2 蛋白结构

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (47 - 323)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (47 - 74)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (81 - 106)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (117 - 147)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (158 - 180)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (206 - 234)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (242 - 272)

7tmA_CXCR1_2

7tmA_CXCR1_2: cd15178 (291 - 316)

  • 0
  • 100
  • 200
  • 300
  • 359 a.a.
蛋白主名 其他名称

C-X-C chemokine receptor type 2

CXC-R2

CXCR-2

GRO/MGSA receptor

IL-8 receptor alpha chain

IL-8R B

chemokine (C-X-C) receptor 2

high affinity interleukin-8 receptor B

interleukin 8 receptor, beta

interleukin-8 receptor type B

相关产品

Clinical Phase
生物活性分子 (10)
目录号 产品名 作用方式
纯度 Phase
HY-15251 Reparixin Inhibitor 99.95% Phase 3
HY-15252 Reparixin L-lysine salt Inhibitor 99.66% Phase 3
HY-19519A Ladarixin sodium Antagonist 99.15% Phase 3
HY-10198 Navarixin Antagonist 98.90% Phase 2
HY-13848 AZD8797 98.73% Phase 2
HY-19855 AZD-5069 Antagonist 99.76% Phase 2
HY-119339 SX-682 Inhibitor 99.67% Phase 2
HY-19768 Danirixin Antagonist 98.45% Phase 2
HY-18263C Elubrixin tosylate Antagonist 99.78% Phase 2
HY-18263A Elubrixin Antagonist / Phase 2
Pre-clinical Phase
生物活性分子 (19)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-16711 SB225002 Antagonist 99.87% 否
HY-50688 SB-265610 Antagonist ≥99.0% 否
HY-101407 Nicotinamide N-oxide Antagonist 99.85% 否
HY-101022 CXCR2-IN-1 Inhibitor 99.47% 否
HY-147392 CXCR2 antagonist 8 Antagonist 99.24% 否
HY-120878 CXCR2-IN-2 Antagonist 99.52% 否
HY-13021 SRT3190 Antagonist 99.77% 否
HY-12927 SX-517 Antagonist 99.88% 否
HY-119259 AZD8309 Antagonist 99.98% 否
HY-10011 SCH 563705 Antagonist 99.29% 否
HY-15462 SRT3109 Antagonist 99.82% 否
HY-144784 CXCR2 antagonist 7 Antagonist / 否
HY-144780 CXCR2 antagonist 4 Antagonist / 否
HY-124056 AZ10397767 Antagonist / 否
HY-101407R Nicotinamide N-oxide (Standard) Antagonist / 否
HY-N2573 Corydalmine Inhibitor / 否
HY-144783 CXCR2 antagonist 6 Antagonist / 否
HY-144781 CXCR2 antagonist 5 Antagonist / 否
HY-P4846 Ac-Pro-Gly-Pro-OH Agonist / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cxcr2 NCBI NCBI:3579
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z