2. Gene
  3. MAP3K8 - mitogen-activated protein kinase kinase kinase 8 Gene

MAP3K8 - mitogen-activated protein kinase kinase kinase 8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：丝裂原活化蛋白激酶激酶激酶 8

种属: Homo sapiens

同用名: COT; EST; ESTF; TPL2; AURA2; MEKK8; Tpl-2; c-COT

基因 ID: 1326 | 基因类型: protein coding

关于 MAP3K8

Cytogenetic location: 10p11.23 Genomic coordinates (GRCh38): 10:30,434,021-30,461,833 (from NCBI)

This gene has 7 transcripts (splice variants), 199 orthologues, 35 paralogues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 18.4), appendix (RPKM 6.8) and 17 other tissues.

功能概要

该基因是一种致癌基因，编码丝氨酸/苏氨酸蛋白激酶家族的成员。编码的蛋白质定位于细胞质，可以激活 MAP 激酶和 JNK 激酶途径。这种蛋白质被证明可以激活 IkappaB 激酶，从而诱导 NF-kappaB 的核生成。还发现这种蛋白质在 T 淋巴细胞活化过程中促进 TNF-α 和 IL-2 的产生。该基因还可以利用下游的框内翻译起始密码子，从而产生包含较短 N 末端的亚型。较短的亚型已显示出较弱的转化活性。交替剪接导致编码相同蛋白质的多个转录变体。[RefSeq 提供，2011 年 9 月]

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

MAP3K8 基因产物(9)

mRNA Protein Name
XM_017015714.2 XP_016871203.1 mitogen-activated protein kinase kinase kinase 8 isoform X2
XM_017015710.1 XP_016871199.1 mitogen-activated protein kinase kinase kinase 8 isoform X1
XM_047424623.1 XP_047280579.1 mitogen-activated protein kinase kinase kinase 8 isoform X1
NM_005204.4 NP_005195.2 mitogen-activated protein kinase kinase kinase 8
XM_047424622.1 XP_047280578.1 mitogen-activated protein kinase kinase kinase 8 isoform X1
NM_001320961.2 NP_001307890.1 mitogen-activated protein kinase kinase kinase 8
XM_017015709.3 XP_016871198.1 mitogen-activated protein kinase kinase kinase 8 isoform X1
XM_047424624.1 XP_047280580.1 mitogen-activated protein kinase kinase kinase 8 isoform X1
NM_001244134.1 NP_001231063.1 mitogen-activated protein kinase kinase kinase 8

MAP3K8 蛋白结构

Pkinase

Pkinase: Protein kinase domain (144 - 386)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 467 a.a.
蛋白主名 其他名称

mitogen-activated protein kinase kinase kinase 8

Ewing sarcoma transformant

augmented in rheumatoid arthritis 2

cot (cancer Osaka thyroid) oncogene

proto-oncogene c-Cot

proto-oncogene serine/threoine protein kinase

tumor progression locus 2

重组 MAP3K8 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75921 MAP3K8/TPL-2 Protein, Human (sf9, GST) P41279 (M30-R397) ≥95%

关联疾病

疾病名称 别名
Ewing Sarcoma

Neuroepithelioma

Ewing'S Tumor

Ewings Sarcoma

Ewing'S Sarcoma

Peripheral Neuroepithelioma

Primitive Neuroectodermal Tumor

ES

Ewings Sarcoma-Primitive Neuroectodermal Tumor

Localized Peripheral Primitive Neuroectodermal Tumor

Peripheral Primitive Neuroectodermal Tumor

Ewing Tumor

Sarcoma, Ewing'S

Extraosseous Ewing Tumor

Askin Tumor

Ewing'S Family Localized Tumor

Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing Sarcoma

Localized Ewing'S Sarcoma

Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing'S Tumor

Pnet Of Thoracopulmonary Region

Ewing Family Of Tumors

Tumor Of The Ewing Family

Skeletal Ewing Sarcoma

Osseous Ewing Sarcoma

Ppnet

Peripheral Pnet

Extraskeletal Ewing Sarcoma

Eoe

Extraosseous Ewing Sarcoma

Extraskeletal Ewing Tumor

Esft

Ewing Sarcoma Family Of Tumors

Pne

Pnet

Pnet Of The Chest Wall

Sarcoma, Ewing

Neuroectodermal Tumors, Primitive, Peripheral

Neuroectodermal Tumor, Primitive

Disorder Of Eye

Askin'S Tumor

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

Neuroepithelioma, Peripheral
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Spitzoid Melanoma

Atypical Spitz Nevus
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12358 Tpl2 Kinase Inhibitor 1 Inhibitor 99.22% 否

直系同源

种属 基因名 来源 基因 ID
Felis catus MAP3K8 VGNC VGNC:97497
Bos taurus MAP3K8 VGNC VGNC:31202
Canis familiaris MAP3K8 VGNC VGNC:42979
Rattus norvegicus MAP3K8 RGD RGD:620969
Mus musculus MAP3K8 MGD MGI:1346878
Macaca mulatta MAP3K8 VGNC VGNC:81464
Others MAP3K8 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z