Il12a - interleukin 12a Gene

中文名称：白细胞介素 12 a

种属: Mus musculus

同用名: p35; Ll12a; Il-12a; IL-12p35

关于 Il12a

功能概要

该基因编码的蛋白可启动白细胞介素 12 β 亚基结合活性。有助于细胞因子活性。作用于多个过程的上游或内部，包括 T-helper 1 细胞激活；对原生动物的防御反应；和 T 细胞活化的正调节。位于细胞表面；细胞质；和细胞外空间。白细胞介素 12 复合体的一部分。在大脑中表达；肺;小肠;睾丸;和胸腺。该基因与丙型肝炎有关的人类直系同源物；肝细胞癌；和原发性胆汁性胆管炎。与人 IL12A（白细胞介素 12A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables interleukin-12 beta subunit binding activity. Contributes to cytokine activity. Acts upstream of or within several processes, including T-helper 1 cell activation; defense response to protozoan; and positive regulation of T cell activation. Located in cell surface; cytoplasm; and extracellular space. Part of interleukin-12 complex. Is expressed in brain; lung; small intestine; testis; and thymus. Human ortholog(s) of this gene implicated in hepatitis C; hepatocellular carcinoma; and primary biliary cholangitis. Orthologous to human IL12A (interleukin 12A). [provided by Alliance of Genome Resources, Apr 2022]