Mmp12 - matrix metallopeptidase 12 Gene

中文名称：基质金属肽酶 12

种属: Mus musculus

同用名: MME; Mmel

关于 Mmp12

功能概要

该基因编码细胞外基质降解酶基质金属蛋白酶家族的一个成员，这些酶参与组织重塑、伤口修复、动脉粥样硬化进展和肿瘤侵袭。编码的前原蛋白经过蛋白水解加工，产生成熟的锌依赖性内肽酶。缺乏编码蛋白的小鼠降解细胞外基质成分的能力降低，不会因长期暴露于香烟烟雾而发展为肺气肿，并且在细菌感染时表现出清除率受损和死亡率增加。该基因位于 9 号染色体上的其他基质金属蛋白酶基因簇中。交替剪接产生编码不同亚型的多个转录变体。 [RefSeq 提供，2016 年 2 月]

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase Enzyme. Mice lacking the encoded protein have a diminished capacity to degrade extracellular matrix components, do not develop emphysema in response to long-term exposure to cigarette smoke, and exhibit impaired clearance and increased mortality upon Bacterial infection. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. Alternate splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]