Mmp9 - matrix metallopeptidase 9 Gene

中文名称：基质金属肽酶 9

种属: Mus musculus

同用名: Clg4b; Gel B; MMP-9; B/MMP9; pro-MMP-9

关于 Mmp9

功能概要

该基因编码细胞外基质降解酶基质金属蛋白酶家族的一个成员，这些酶参与组织重塑、伤口修复、动脉粥样硬化进展和肿瘤侵袭。编码的前原蛋白经过蛋白水解处理，产生成熟的锌依赖性内肽酶，可降解 IV、V 和 XI 型胶原蛋白以及弹性蛋白。缺乏编码蛋白的小鼠表现出骨骼生长板血管化和骨化的异常模式，所有肿瘤阶段的角质形成细胞过度增殖减少，侵袭性肿瘤的发生率降低，以及对实验性自身免疫性脑脊髓炎的抵抗力。 [RefSeq 提供，2016 年 2 月]

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase Enzyme that degrades collagens of type IV, V and XI, and elastin. Mice lacking the encoded protein exhibit an abnormal pattern of skeletal growth plate vascularization and ossification, reduced keratinocyte hyperproliferation at all neoplastic stages, a decreased incidence of invasive tumors, and resistance to experimental autoimmune encephalomyelitis. [provided by RefSeq, Feb 2016]