DNASE1L3 - deoxyribonuclease 1 like 3 Gene

中文名称：脱氧核糖核酸酶 1 样 3

种属: Homo sapiens

同用名: LSD; DHP2; SLEB16; DNAS1L3

基因 ID: 1776 | 基因类型: protein coding

关于 DNASE1L3

Cytogenetic location: 3p14.3 Genomic coordinates (GRCh38): 3:58,192,257-58,210,972 (from NCBI)

This gene has 7 transcripts (splice variants), 154 orthologues, 3 paralogues and is associated with 3 phenotypes. Biased expression in spleen (RPKM 118.4), liver (RPKM 61.9) and 11 other tissues.

功能概要

该基因编码脱氧核糖核酸酶 I 家族的一个成员。编码的蛋白质水解 DNA，不受肌动蛋白抑制，并在细胞凋亡过程中介导 DNA 的分解。该基因的突变是系统性红斑狼疮 16 的一个原因。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2012 年 2 月]

This gene encodes a member of the deoxyribonuclease I family. The encoded protein hydrolyzes DNA, is not inhibited by actin, and mediates the breakdown of DNA during Apoptosis. Mutations in this gene are a cause of systemic lupus erythematosus-16. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

DNASE1L3 基因产物(2)

mRNA	Protein	Name
NM_001256560.2	NP_001243489.1	deoxyribonuclease gamma isoform 2 precursor
NM_004944.4	NP_004935.1	deoxyribonuclease gamma isoform 1 precursor

DNASE1L3 蛋白结构

Exo_endo_phos

0
100
200
305 a.a.

蛋白主名

其他名称

deoxyribonuclease gamma

DNase I homolog protein 2

重组 DNASE1L3 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71543	DNASE1L3 Protein, Human (GST)	Q13609 (M21-S305)	≥95%

关联疾病

疾病名称

别名

Systemic Lupus Erythematosus 16

SLEB16	Autosomal Systemic Lupus Erythematosus
Autosomal Sle	Familial Sle
Familial Systemic Lupus Erythematosus	Lupus Erythematosus, Systemic, Type 16

Hypocomplementemic Urticarial Vasculitis

Anti-C1q Vasculitis	Mac Duffie Hypocomplementemic Urticarial Vasculitis
Mac Duffie Syndrome	Mcduffie Hypocomplementemic Urticarial Vasculitis
Mcduffie Syndrome

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Lymphadenitis

Acute Lymphadenitis	Chronic Lymphadenitis
Adenitis	Chronic Adenitis
Acute Adenitis	Inflammation Of Lymph Node
Adenitis Nos	Inflammation Of Gland
Lymphatic Gland Inflammation	Lymph Gland Inflammation
Polyadenitis	Chronic Adenitis Of Any Lymph Node Except Mesenteric
Chronic Lymphadenitis Except Mesenteric	Chronic Non-Specific Lymphadenitis

Chilblain Lupus 1

Chilblain Lupus	CHBL1
Chilblain Lupus Erythematosus	Chle
Hutchinson Lupus	Chilblain Lupus, Type 1

Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations

Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations	Crv
Rvcl	Rvcl-S
Vasculopathy, Retinal, With Cerebral Leukodystrophy	Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Retinal Vasculopathy With Cerebral Leukodystrophy	Retinal Vasculopathy And Cerebral Leukoencephalopathy
Hereditary Vascular Retinopathy	Hvr
RVCLS	Cerebroretinal Vasculopathy, Hereditary
Cerebroretinal Vasculopathy	Herns
Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly	Hereditary Cerebroretinal Vasculopathy
Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke	Hereditary Systemic Angiopathy
Hsa	Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations
Adrvcl	Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy
Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke	Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03897	DNASE1L3 Human Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	DNASE1L3	RGD	RGD:620669
Bos taurus	DNASE1L3	VGNC	VGNC:28135
Felis catus	DNASE1L3	VGNC	VGNC:61554
Canis familiaris	DNASE1L3	VGNC	VGNC:40025
Mus musculus	DNASE1L3	MGD	MGI:1314633
Macaca mulatta	DNASE1L3	VGNC	VGNC:71949
Others	DNASE1L3	NCBI

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DNASE1L3 - deoxyribonuclease 1 like 3 Gene

关于 DNASE1L3

功能概要

DNASE1L3 基因产物(2)

DNASE1L3 蛋白结构

重组 DNASE1L3 蛋白

关联疾病

直系同源

热门区域

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DNASE1L3 - deoxyribonuclease 1 like 3 Gene

关于 DNASE1L3

功能概要

DNASE1L3 基因产物(2)

DNASE1L3 蛋白结构

重组 DNASE1L3 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z