Tgfb1 - transforming growth factor, beta 1 Gene

中文名称：转化生长因子， β 1

种属: Mus musculus

同用名: Tgfb; Tgfb-1; TGFbeta1; TGF-beta1

关于 Tgfb1

功能概要

该基因编码 TGF-β（转化生长因子-β）蛋白质超家族的分泌配体。该家族的配体结合各种 TGF-β 受体，导致调节基因表达的 SMAD 家族转录因子的募集和激活。编码的前原蛋白经过蛋白水解处理以生成潜伏相关肽 (LAP) 和成熟肽，并且以由成熟肽同二聚体、LAP 同二聚体和潜伏 TGF-β 结合蛋白组成的潜伏形式被发现，或者以仅由成熟肽同源二聚体组成的活性形式存在。成熟肽还可以与其他 TGF-β 家族成员形成异二聚体。这种编码的蛋白质调节细胞增殖、分化和生长，并可以调节其他生长因子的表达和激活，包括干扰素 γ 和肿瘤坏死因子 α。缺乏该基因功能拷贝的小鼠会发展为严重的多灶性炎症性疾病、卵黄囊缺陷和结肠癌。 [RefSeq 提供，2016 年 8 月]

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. Mice lacking a functional copy of this gene develop severe multifocal inflammatory disease, yolk sac defects and colon Cancer. [provided by RefSeq, Aug 2016]