Map3k5 - mitogen-activated protein kinase kinase kinase 5 Gene

中文名称：丝裂原活化蛋白激酶激酶激酶 5

种属: Mus musculus

同用名: ASK; ASK1; Mekk5; MAPKKK5; 7420452D20Rik

关于 Map3k5

功能概要

该基因编码的蛋白可启动 MAP 激酶激酶激酶活性和蛋白激酶结合活性。参与多个过程，包括响应内质网应激的内在凋亡信号通路； JNK 级联的正调控；和细胞死亡的正调节。作用于多个过程的上游或内部，包括细胞对活性氮物质的反应；细胞内信号转导；和 MAPK 级联的正调控。预计位于细胞质中。预计是 IRE1-TRAF2-ASK1 复合物和蛋白激酶复合物的一部分。以多种结构表达，包括消化系统；鳃弓;中枢神经系统;心;和感觉器官。该基因的人类直系同源物与亨廷顿病有关。与人 MAP3K5（丝裂原活化蛋白激酶激酶激酶 5）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables MAP kinase kinase kinase activity and protein kinase binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of JNK cascade; and positive regulation of cell death. Acts upstream of or within several processes, including cellular response to reactive nitrogen species; intracellular signal transduction; and positive regulation of MAPK cascade. Predicted to be located in cytoplasm. Predicted to be part of IRE1-TRAF2-ASK1 complex and protein kinase complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5). [provided by Alliance of Genome Resources, Apr 2022]