2. Gene
  3. Ccr8 - C-C motif chemokine receptor 8 Gene

Ccr8 - C-C motif chemokine receptor 8 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：CC 基序趋化因子受体 8

种属: Rattus norvegicus

基因 ID: 301066 | 基因类型: protein coding

关于 Ccr8

Primary_assembly 8: 119,826,568-119,827,629 forward strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 236 orthologues, 24 paralogues and is associated with 3 phenotypes.

功能概要

预测该基因编码的蛋白可启动 CC 趋化因子结合活性和 CC 趋化因子受体活性。预计参与多个过程，包括钙介导的信号传导；细胞趋化性；和细胞溶质钙离子浓度的正调节。预计在趋化性上游或趋化性内起作用。预计是膜的组成部分。预计在质膜外侧活跃。哮喘和肺纤维化的生物标志物。与人 CCR8（CC 基序趋化因子受体 8）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable C-C chemokine binding activity and C-C Chemokine Receptor activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within chemotaxis. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Biomarker of asthma and pulmonary fibrosis. Orthologous to human CCR8 (C-C motif Chemokine Receptor 8). [provided by Alliance of Genome Resources, Apr 2022]

Ccr8 基因产物(1)

mRNA Protein Name
XM_008766702.3 XP_008764924.1 C-C chemokine receptor type 8

Ccr8 蛋白结构

7tm_GPCRs

7tm_GPCRs: cl28897 (33 - 308)

7tm_GPCRs

7tm_GPCRs: cd14964 (35 - 59)

7tm_GPCRs

7tm_GPCRs: cd14964 (68 - 89)

7tm_GPCRs

7tm_GPCRs: cd14964 (104 - 126)

7tm_GPCRs

7tm_GPCRs: cd14964 (149 - 165)

7tm_GPCRs

7tm_GPCRs: cd14964 (193 - 216)

7tm_GPCRs

7tm_GPCRs: cd14964 (234 - 256)

7tm_GPCRs

7tm_GPCRs: cd14964 (276 - 301)

  • 0
  • 100
  • 200
  • 300
  • 353 a.a.
蛋白主名 其他名称

C-C chemokine receptor type 8

chemokine (C-C motif) receptor 8

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-101038A ZK756326 dihydrochloride Agonist 99.88% 否
HY-122219 R243 Antagonist 98.01% 否
HY-119217 AZ084 Antagonist 99.69% 否
HY-124416 ML604086 Inhibitor 99.80% 否
HY-121885 LMD-009 Agonist 99.76% 否
HY-144197 CCR8 antagonist 1 Antagonist 98.71% 否
HY-144200 CCR8 antagonist 2 Antagonist 99.71% 否
HY-153669 SB-649701 Antagonist / 否
HY-160647 CCR8 antagonist 3 Antagonist / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ccr8 NCBI NCBI:1237
Macaca fascicularis Ccr8 NCBI NCBI:102132857
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