CCL3L3 - C-C motif chemokine ligand 3 like 3 Gene

中文名称：CC 基序趋化因子配体 3 like 3

种属: Homo sapiens

同用名: LD78; 464.2; SCYA3L; G0S19-2; SCYA3L1; D17S1718; LD78BETA

关于 CCL3L3

功能概要

该基因是聚集在 17 号染色体 q 臂上的几个细胞因子基因之一。细胞因子是一个分泌蛋白家族，在炎症和免疫调节过程中发挥作用。该基因编码的蛋白质与多种趋化因子受体结合，包括趋化因子结合蛋白 2 和趋化因子 (CC 基序) 受体 5 (CCR5) 。 CCR5 是 HIV 的辅助受体，该蛋白与 CCR5 的结合可抑制 HIV 进入。该基因的拷贝数因人而异，大多数个体有 1-6 个拷贝，少数个体有 0 个或 6 个以上的拷贝。关于该基因的拷贝数变异及其与疾病易感性的相关性存在相互矛盾的报道。[RefSeq 提供，2014 年 4 月]

This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility.[provided by RefSeq, Apr 2014]