2. Gene
  3. PRKAB1 - protein kinase AMP-activated non-catalytic subunit beta 1 Gene

PRKAB1 - protein kinase AMP-activated non-catalytic subunit beta 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白激酶 AMP 激活的非催化亚基 β 1

种属: Homo sapiens

同用名: AMPK; HAMPKb

基因 ID: 5564 | 基因类型: protein coding

关于 PRKAB1

Cytogenetic location: 12q24.23 Genomic coordinates (GRCh38): 12:119,667,952-119,681,619 (from NCBI)

This gene has 10 transcripts (splice variants), 285 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 25.5), bone marrow (RPKM 15.9) and 25 other tissues.

功能概要

该基因编码的蛋白质是 AMP 活化蛋白激酶 (AMPK) 的调节亚基。 AMPK 是一种异源三聚体，由一个 α 催化亚基以及非催化 β 和 γ 亚基组成。 AMPK 是一种重要的能量感应酶，可监测细胞能量状态。响应细胞代谢应激，AMPK 被激活，从而使乙酰辅酶 A 羧化酶 (ACC) 和 β-羟基β-甲基戊二酰辅酶 A 还原酶 (HMGCR) 磷酸化和失活，这些酶是参与调节脂肪酸和胆固醇从头生物合成的关键酶.该亚基可能是 AMPK 活性的正调节因子。该亚基的豆蔻酰化和磷酸化已被证明会影响 AMPK 的酶活性和细胞定位。该亚基也可作为衔接分子介导 AMPK 复合物的结合。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing Enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates Acetyl-CoA Carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and Cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the Enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]

PRKAB1 基因产物(1)

mRNA Protein Name
NM_006253.5 NP_006244.2 5'-AMP-activated protein kinase subunit beta-1

PRKAB1 蛋白结构

AMPKBI

AMPKBI: 5'-AMP-activated protein kinase beta subunit, interaction domain (191 - 270)

  • 0
  • 100
  • 200
  • 270 a.a.
蛋白主名 其他名称

5'-AMP-activated protein kinase subunit beta-1

5'-AMP-activated protein kinase beta-1 subunit

重组 PRKAB1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76141 AMPK gamma 1/beta 1/alpha 1 Heterotrimer Protein, Human (sf9, His-GST) P54619 (M1-P331)&Q9Y478 (M1-I270)&Q13131 (M1-Q559) ≥95%
HY-P76142 AMPK gamma 1/beta 1/alpha 2 Heterotrimer Protein, Human (sf9, His-GST) P54619 (M1-P331)&Q9Y478 (M1-I270)&P54646 (M1-R552) ≥95%

关联疾病

疾病名称 别名
Krabbe Disease

Globoid Cell Leukodystrophy

Galactosylceramide Beta-Galactosidase Deficiency

Galc Deficiency

Galactocerebrosidase Deficiency

GLD

Globoid Cell Leukoencephalopathy

Diffuse Globoid Body Sclerosis

Gcl

Leukodystrophy, Globoid Cell

Krabbe'S Leukodystrophy

Krabbe Leukodystrophy

KRB

Beta Galactocerebrosidase Deficiency

Krabbe'S Disease

Galactosylceramidase Deficiency Disease

Galactosylceramide Lipidosis

Galactosylcerebrosidase Deficiency

Galactosylsphingosine Lipidosis

Psychosine Lipidosis

Galactosylceramidase Deficiency

Infantile Globoid Cell Leukodystrophy

Krabbe Brain Sclerosis
Hyperglycemia
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Kidney Cancer

Renal Cancer

Renal Carcinoma

Kidney Neoplasm

Malignant Neoplasm Of Kidney Except Pelvis

Malignant Tumour Of Kidney

Kidney Neoplasms

Cancer, Kidney

Cancer, Renal

Malignant Neoplasm Of Kidney

Renal Cell Carcinoma
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11102 PRKAB1 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PRKAB1 VGNC VGNC:44969
Mus musculus PRKAB1 MGD MGI:1336167
Bos taurus PRKAB1 VGNC VGNC:33319
Rattus norvegicus PRKAB1 RGD RGD:71057
Macaca mulatta PRKAB1 VGNC VGNC:76401
Felis catus PRKAB1 VGNC VGNC:69047
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