UBE2H - ubiquitin conjugating enzyme E2 H Gene

中文名称：泛素结合酶 E2 H

种属: Homo sapiens

同用名: GID3; UBC8; UBCH; UBCH2; E2-20K

关于 UBE2H

功能概要

用泛素修饰蛋白质是靶向异常或短寿命蛋白质进行降解的重要细胞机制。泛素化至少涉及三类酶：泛素激活酶或 E1、泛素结合酶或 E2，以及泛素-蛋白质连接酶或 E3。该基因编码 E2 泛素结合酶家族的成员。编码的蛋白质序列与小鼠同源物 100% 相同，与青蛙和斑马鱼同源物 98% 相同。已发现该基因的三个可变剪接转录物变体，它们编码不同的亚型。[RefSeq 提供，2011 年 2 月]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]