Mmp9 - matrix metallopeptidase 9 Gene

中文名称：基质金属肽酶 9

种属: Rattus norvegicus

关于 Mmp9

功能概要

该基因编码的蛋白可启动纤连蛋白结合活性和金属肽酶活性。参与多个过程，包括细胞对细胞基质粘附的反应；对细胞因子刺激的细胞反应；和细胞对铁 (III) 离子的反应。位于细胞外空间。部分含蛋白质复合物。用于研究动脉疾病（多种）；脑缺血（多发）；充血性心力衰竭;肾小球硬化;和肺部疾病（多种）。多种疾病的生物标志物，包括动脉疾病（多种）；脑部疾病（多种）；慢性阻塞性肺病（多发性）；糖代谢疾病（多种）；和肾脏疾病（多种）。该基因的人类直系同源基因与多种疾病有关，包括唐氏综合症；无牙症;动脉疾病（多发性）；自身免疫性疾病（多种）；和慢性阻塞性肺病（多发性）。与人 MMP9（基质金属肽酶 9）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables fibronectin binding activity and metallopeptidase activity. Involved in several processes, including cellular response to cell-matrix adhesion; cellular response to cytokine stimulus; and cellular response to iron(III) ion. Located in extracellular space. Part of protein-containing complex. Used to study artery disease (multiple); brain ischemia (multiple); congestive heart failure; glomerulosclerosis; and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); chronic obstructive pulmonary disease (multiple); glucose metabolism disease (multiple); and kidney disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune disease (multiple); and chronic obstructive pulmonary disease (multiple). Orthologous to human MMP9 (matrix metallopeptidase 9). [provided by Alliance of Genome Resources, Apr 2022]