1. Gene
  2. FCRL5 - Fc receptor like 5 Gene

FCRL5 - Fc receptor like 5 Gene

中文名称:Fc 受体样 5

种属: Homo sapiens

同用名: CD307; FCRH5; IRTA2; BXMAS1; CD307e; PRO820

基因 ID: 83416 | 基因类型: protein coding

关于 FCRL5

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:157,513,377-157,552,515 (from NCBI)

This gene has 8 transcripts (splice variants), 83 orthologues and 17 paralogues. Biased expression in lymph node (RPKM 14.3), spleen (RPKM 11.3) and 8 other tissues.

功能概要

该基因编码免疫球蛋白受体超家族和 Fc 受体样家族的成员。该基因和其他几个 Fc 受体样基因成员聚集在 1 号染色体的长臂上。编码的蛋白质是一种单程 I 型膜蛋白,包含 8 个免疫球蛋白样 C2 型结构域。该基因与 B 细胞发育和淋巴瘤形成有关。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供,2010 年 9 月]

This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]

FCRL5 基因产物(2)

mRNA Protein Name
NM_001195388.2 NP_001182317.1 Fc receptor-like protein 5 isoform 2 precursor
NM_031281.3 NP_112571.2 Fc receptor-like protein 5 isoform 1 precursor

FCRL5 蛋白结构

Ig_2

Ig_2: Immunoglobulin domain (27 - 96)

Ig_2

Ig_2: Immunoglobulin domain (107 - 185)

Ig_2

Ig_2: Immunoglobulin domain (192 - 273)

Ig_2

Ig_2: Immunoglobulin domain (287 - 373)

Ig_2

Ig_2: Immunoglobulin domain (380 - 466)

Ig_2

Ig_2: Immunoglobulin domain (473 - 559)

Ig_3

Ig_3: Immunoglobulin domain (565 - 638)

Ig_3

Ig_3: Immunoglobulin domain (658 - 731)

Ig_2

Ig_2: Immunoglobulin domain (755 - 835)

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  • 977 a.a.
蛋白主名 其他名称

Fc receptor-like protein 5

fc receptor homolog 5

重组 FCRL5 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77651 FcRH5/FcRL5 Protein, Human (HEK293, His-Avi) Q96RD9-1 (Q16-G851) ≥95%
HY-P700302 FcRH5/FcRL5 Protein, Human (HEK293, His) AAK93971 (Q16-G851) > 95% as determined by Tris-Bis PAGE.

关联疾病

疾病名称 别名
Hairy Cell Leukemia

Hcl-V

Hairy Cell Leukemia Variant

Hairy Cell Leukaemia Variant

Hcl

Leukemic Reticuloendotheliosis

Leukemic Reticuloendotheliosis Variant

Prolymphocytic Variant Of Hcl

Prolymphocytic Variant Of Hairy Cell Leukemia

Leukemia Hairy Cell

Leukemia, Hairy Cell

Leukaemic Reticuloendotheliosis

Lre - [Leukemic Reticuloendotheliosis]

Hairy-Cell Leukaemia, Nos

Hcl - [Hairy Cell Leukaemia]

Hairy-Cell Leukaemia Without Mention Of Remission

Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos

Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus FCRL5 RGD RGD:1589379
Bos taurus FCRL5 VGNC VGNC:59181
Canis familiaris FCRL5 VGNC VGNC:49722
Felis catus FCRL5 VGNC VGNC:62216
Macaca mulatta FCRL5 VGNC VGNC:99950
Mus musculus FCRL5 MGD MGI:3053558
Others FCRL5 NCBI