CD3E - CD3 epsilon subunit of T-cell receptor complex Gene

中文名称：T 细胞受体复合物的 CD3 epsilon 亚基

种属: Homo sapiens

同用名: T3E; TCRE; IMD18; CD3epsilon

关于 CD3E

功能概要

该基因编码的蛋白质是 CD3-epsilon 多肽，它与 CD3-gamma、-delta 和 -zeta 以及 T 细胞受体 alpha/beta 和 gamma/delta 异二聚体一起形成 T 细胞受体-CD3 复合物.该复合物在将抗原识别与多种细胞内信号转导途径偶联方面起着重要作用。编码 epsilon、γ 和 delta 多肽的基因位于 11 号染色体上的同一簇中。epsilon 多肽在 T 细胞发育中起着重要作用。该基因的缺陷会导致免疫缺陷。该基因还与女性易患 I 型糖尿病有关。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]