TMPRSS11D - transmembrane serine protease 11D Gene

中文名称：跨膜丝氨酸蛋白酶 11D

种属: Homo sapiens

同用名: ASP; HAT

关于 TMPRSS11D

功能概要

该基因编码从粘膜下浆液腺释放到粘膜上的胰蛋白酶样丝氨酸蛋白酶。它是一种 II 型整合膜蛋白，在催化区序列中与人肝蛋白酶、肠肽酶、顶糖和肥大细胞类胰蛋白酶具有 29-38% 的同一性。非催化区域与其他已知蛋白质几乎没有相似之处。这种蛋白质可能独立于或与气道粘液或支气管分泌物中的其他物质合作，在粘膜上的宿主防御系统中发挥某些生物学作用。该蛋白通过蛋白水解切割和激活病毒包膜糖蛋白，促进病毒进入宿主细胞。[RefSeq 提供，2021 年 8 月]

This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. This protein facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. [provided by RefSeq, Aug 2021]