2. Antibody-drug Conjugate/ADC Related Cytoskeleton Cell Cycle/DNA Damage
  3. Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin
  4. Glembatumumab vedotin

Glembatumumab vedotin  (Synonyms: CDX-011; CR011-vcMMAE)

目录号: HY-141604
COA 产品使用指南

摩尔计算器

Glembatumumab vedotin (CDX-011) 是一种 ADC (Antibody-Drug Conjugates (ADCs))，包含针对糖蛋白 NMB (GPNMB) 的全人 IgG2 单克隆抗体 (CR011)，并通过蛋白酶敏感的 vc 接头与强效微管蛋白结合细胞毒剂 MMAE 偶联。Glembatumumab vedotin 具有强大的抗癌作用。

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Glembatumumab vedotin Chemical Structure

Glembatumumab vedotin Chemical Structure

CAS No. : 1182215-65-1

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规格 价格 是否有货 数量
1 mg ￥7400
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Glembatumumab vedotin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Glembatumumab vedotin (CDX-011) is an ADC (antibody-drug conjugates (ADCs)) comprising a fully human IgG2 monoclonal antibody (CR011) directed against glycoprotein NMB (GPNMB) and conjugated to the potent tubulinbinding cytotoxic agent MMAE via a protease-sensitive vc linker. Glembatumumab vedotin has potent anticancer effects[1].

体外研究
(In Vitro)

Glembatumumab vedotin 与肿瘤上的 GPNMB 结合，复合物被内化，MMAE 通过溶酶体区室中 vc 接头的蛋白水解切割释放。MMAE 抑制微管并导致细胞周期停滞导致肿瘤细胞死亡[1]。
Glembatumumab vedotin（1-125 μg/mL；96 小时）表现出骨肉瘤细胞毒活性[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Glembatumumab vedotin 相关抗体:

Cell Viability Assay[3]

Cell Line: Osteosarcoma cell lines
Concentration: 1 μg/mL to 125 μg/mL
Incubation Time: 96 hours
Result: Demonstrated osteosarcoma cytotoxic activity.
体内研究
(In Vivo)

Glembatumumab vedotin（CR011-vcMMAE；1.25-80 mg/kg；静脉注射；每 4 天一次；持续 16 天）在人类 SK-MEL-2 和 SK-MEL-5 黑色素瘤异种移植模型中显示出短期抗肿瘤作用（抑制肿瘤生长）和长期作用（完全消退）[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic mice (6-week-old) injected with human SK-MEL-2 and SK-MEL-5 melanoma cells[2]
Dosage: 1.25 mg/kg, 2.5 mg/kg, 5 mg/kg, 10 mg/kg, 20 mg/kg, 40 mg/kg, 60 mg/kg, 80 mg/kg
Administration: i.v.; every 4 days; for 16 days
Result: Showed inhibition of tumor growth.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

-80°C, protect from light
纯度 & 产品资料
参考文献

Glembatumumab vedotin 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glembatumumab vedotin1182215-65-1CDX-011 CR011-vcMMAECDX011CDX 011Antibody-Drug Conjugates (ADCs)Microtubule/TubulinAntibody-Drug ConjugatesGPNMBADCCR011MMAEanticancer effectsInhibitorinhibitorinhibit

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