2. PI3K/Akt/mTOR Stem Cell/Wnt Neuronal Signaling JAK/STAT Signaling TGF-beta/Smad Epigenetics
  3. GSK-3 Tau Protein AAK1 Pim PKC
  4. GSK-3β inhibitor 13

GSK-3β inhibitor 13 (compound 47) 是一种具有口服活性且有效的 GSK-3β 抑制剂，具有血脑通透性。GSK-3β inhibitor 13 抑制 GSK-3β 和 GSK-3α，IC50 分别为 0.73 nM 和 0.35 nM。GSK-3β inhibitor 13 显着降低 tau 的磷酸化 (IC50=58 nM)，而磷酸化的 tau 会引起与阿尔茨海默相关的神经原纤维缠结的形成。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

GSK-3β inhibitor 13 Chemical Structure

GSK-3β inhibitor 13 Chemical Structure

CAS No. : 2227316-74-5

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

GSK-3β inhibitor 13 相关抗体

Top Publications Citing Use of Products

查看 GSK-3 亚型特异性产品:

查看所有亚型
GSK-3 GSK-3α GSK-3β

查看 PKC 亚型特异性产品:

查看所有亚型
PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GSK-3β inhibitor 13 (compound 47) is an orally active and potent GSK-3β inhibitor with blood-brain permeability. GSK-3β inhibitor 13 inhibits GSK-3β and GSK-3α with IC50s of 0.73 nM and 0.35 nM, respectively. GSK-3β inhibitor 13 significantly decreases the phosphorylation of tau (IC50=58 nM), which leads the formation of the neurofibrillary tangles associated with Alzheimer's disease[1].

IC50 & Target[1]

GSK-3β

0.73 nM (IC50)

GSK-3α

0.35 nM (IC50)

PKCθ

0.36 μM (IC50)

PIM1

0.38 μM (IC50)

AAK1

0.20 μM (IC50)

体内研究
(In Vivo)

GSK-3β inhibitor 13 在血浆中的暴露量为 3.8 μM，在脑中的暴露量为 1.3 μM，导致脑-血浆 (B/P) 比率为 0.34[1]。
GSK-3β inhibitor 13 (30 mg/kg；口服；单剂量) 在 LaFerla 3xTg-C57BL6 小鼠中降低 52% 的 pTau396 水平[1]。

在小鼠中的药代动力学分析[1]

Route Dose (mg/kg) CL (mL/mL/kg) Vss (L/kg) MRT (h) t1/2 (h)
i.v. 2 3.8 1.1 4.8 5.2
Route Dose (mg/kg) AUCtot (μM·h) Cmax (μM) F (%)
p.o. 10 68.3 7.8 64

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

414.46

Formula

C23H22N6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GSK-3β inhibitor 13 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK-3β inhibitor 132227316-74-5GSK-3Tau ProteinAAK1PimPKCGlycogen synthase kinase-3Glycogen synthase kinase 3Adaptor-associated Kinase 1AP2-associated kinase 1Pim kinasesProtein kinase CInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
GSK-3β inhibitor 13
目录号：
HY-149054
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z