2. PI3K/Akt/mTOR Stem Cell/Wnt
  3. GSK-3
  4. GSK-3β inhibitor 7

GSK-3β inhibitor 7 是一种 GSK-3β 抑制剂，IC50 值为 5.25 μM。GSK-3β inhibitor 7 可插入 GSK-3β 的 ATP-binding binding 口袋并形成氢键。GSK-3β inhibitor 7 显示出较高的肝细胞葡萄糖摄取率 (83.5%)，可用于糖尿病、炎症、癌症、阿尔茨海默病和双相情感障碍等多种疾病的研究。

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GSK-3β inhibitor 7 Chemical Structure

GSK-3β inhibitor 7 Chemical Structure

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GSK-3β inhibitor 7 相关抗体

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GSK-3 GSK-3α GSK-3β

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GSK-3β inhibitor 7 is a GSK-3β inhibitor with an IC50 value of 5.25 μM. GSK-3β inhibitor 7 is inserted into the ATP-binding binding pocket of GSK-3β and forms hydrogen-bond. GSK-3β inhibitor 7 shows high hepatocyte glucose uptake (83.5%), and can be used in the research of numerous diseases like diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder[1].

IC50 & Target[1]

GSK-3β

5.25 μM (IC50)

体外研究
(In Vitro)

GSK-3β inhibitor 7 (Compound 6x, 5 μΜ, 3 h) shows high glucose uptake (83.5%) in musle L6 cells[1].
GSK-3β inhibitor 7 (0-30 μΜ, 30 min) inhibits GSK-3β with an IC50 value of 5.25 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

GSK-3β inhibitor 7 相关抗体:
体内研究
(In Vivo)

GSK-3β inhibitor 7 (Compound 6x, oral administration, 20 mg/kg) shows favorable drug-like properties (t1/2: 5.4 h, Cmax: 507 ng/mL) and oral bioavailability in rats[1].
GSK-3β inhibitor 7 (intragastric administration, 1 g/kg) displays no acute toxicity at a 1 g/kg dose in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (pharmacokinetic assay)[1]
Dosage: 2 mg/kg, 20 mg/kg
Administration: Intravenous injection (2 mg/kg), oral administration (20 mg/kg)
Result: Pharmacokinetic profile of GSK-3β inhibitor 7 (Compound 6x).
Compound Route Dose (mg/kg) t1/2 (h) Tmax (h) Cmax (ng/mL) AUC0-t (hr•ng/mL) AUC0-∞ (hr•ng/mL) CL (mL/hr/kg) F (%)
GSK-3β inhibitor 7 Oral administration 20 5.40 1.67 507 4265 4501 4536 47.4
GSK-3β inhibitor 7 Intravenous injection 2 8.95 0.08 519 859 948.6 2138.66
F: oral bioavailability.
Animal Model: Male and female mice (acute assay)[1]
Dosage: 1 g/kg
Administration: intragastric administration
Result: Increased body weights, caused no death or obvious weight loss.
Showed no marked pathological damage in important organs (brain, heart, liver, spleen, lung, and kidney).
分子量

547.47

Formula

C27H23BrN4O2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GSK-3β inhibitor 7 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK-3β inhibitor 7GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3DiabetesinflammationcancerAlzheimer's diseasebipolar disorderglucoseHepG2Inhibitorinhibitorinhibit

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