2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis Necroptosis
  4. HDAC-IN-70

HDAC-IN-70 (compound 4c) 为 HDAC6 抑制剂，对 HDAC6、HDAC1、HDAC2 和 HDAC4 的IC50 值分别为 64.13 nM、166 nM、618 nM 和 253 nM。HDAC-IN-70 诱导细胞周期阻滞，凋亡 (apoptosis) 和坏死。HDAC-IN-70 可用于白血病的研究。

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HDAC-IN-70 Chemical Structure

HDAC-IN-70 Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

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HDAC-IN-70 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC-IN-70 (compound 4c) is HDAC6 inhibitor with the IC50 values of 64.13 nM, 166 nM, 618 nM and 253 nM for HDAC6, HDAC1, HDAC2 and HDAC4, respectively. HDAC-IN-70 induces cell cycle arrest, apoptosis and necrotic. HDAC-IN-70 can be used for study of leukemia[1].

IC50 & Target

HDAC6

64.13 nM (IC50)

HDAC1

166 nM (IC50)

HDAC2

618 nM (IC50)

HDAC4

253 nM (IC50)

体外研究
(In Vitro)

HDAC-IN-70 (compound 4c) (0-120 μM) 对 CCRF-CEM 和 MOLT-4 细胞具有细胞毒性，其 IC50 值分别为 1.82 和 6.73 μM[1]。
HDAC-IN-70 (1.82 μM, 24 h) 在 CCRF-CEM 细胞中使周期阻滞在 G2-M 期[1]。
HDAC-IN-70 (1.82 μM, 24 h) 增加 CCRF-CEM 细胞总凋亡和坏死百分比[1]。
HDAC-IN-70 增加 CCRF-CEM 白血病细胞乙酰化组蛋白 H3、H4 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC-IN-70 相关抗体:

Cell Cycle Analysis[1]

Cell Line: CCRF-CEM cells
Concentration: 1.82 μM
Incubation Time: 24 h
Result: Arrested cell cycle at G2-M phase.

Apoptosis Analysis[1]

Cell Line: CCRF-CEM cells
Concentration: 1.82 μM
Incubation Time: 24 h
Result: Increased the percentage of total apoptosis to 80.44%.
分子量

334.33

Formula

C18H14N4O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC-IN-70 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-70HDACApoptosisNecroptosisHistone deacetylasesleukemiaCCRF-CEMMOLT-4apoptosisInhibitorinhibitorinhibit

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目录号：
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