1. Cell Cycle/DNA Damage Epigenetics Apoptosis
  2. HDAC CDK Apoptosis
  3. HDAC1/CDK7-IN-1

HDAC1/CDK7-IN-1 (compound 8e) 是一种 CDK7HDAC1 双重抑制剂,IC50 分别为 893 nM 和 248 nM。HDAC1/CDK7-IN-1 抑制 MDA-MB-231、MCF-7、A549 和 HCT-116 癌细胞的生长。HDAC1/CDK7-IN-1 诱导 HCT-116 细胞的细胞周期停滞和凋亡 (apoptosis),并阻碍 HCT-116 细胞的迁移。

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HDAC1/CDK7-IN-1 Chemical Structure

HDAC1/CDK7-IN-1 Chemical Structure

CAS No. : 2987905-95-1

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  • 生物活性

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生物活性

HDAC1/CDK7-IN-1 (compound 8e) is a dual CDK7 and HDAC1 inhibitor with IC50s of 893 nM and 248 nM, respectively. HDAC1/CDK7-IN-1 inhibits the growth cells of MDA-MB-231, MCF-7, A549, and HCT-116 cancer cells. HDAC1/CDK7-IN-1 induces cell cycle arrest and apoptosis in HCT-116 cells, as well as hindered the migration of HCT-116 cells[1].

IC50 & Target[1]

CDK7

893 nM (IC50)

HDAC1

248 nM (IC50)

分子量

626.10

Formula

C33H32ClN7O4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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产品名称:
HDAC1/CDK7-IN-1
目录号:
HY-156444
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