2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC6-IN-15

HDAC6-IN-15 是一种选择性组蛋白脱乙酰酶 6 (HDAC6) 抑制剂。HDAC6-IN-15 对 HDAC6 具有有效的抑制活性，IC50 值为 38.2 nM。HDAC6-IN-15 可用于癌症和神经退行性疾病的研究。

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HDAC6-IN-15 Chemical Structure

HDAC6-IN-15 Chemical Structure

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HDAC6-IN-15 相关抗体

Top Publications Citing Use of Products

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC6-IN-15 is a selective histone deacetylase 6 (HDAC6) inhibitor. HDAC6-IN-15 has potent inhibitory activity for HDAC6 with IC50 value of 38.2 nM. HDAC6-IN-15 can be used for the research of cancer and neurodegenerative diseases[1].

IC50 & Target

HDAC6

38.2 nM (IC50)

体外研究
(In Vitro)

HDAC6-IN-15 (Compound II-5) 对 HDAC6 具有有效的抑制活性，IC50 值为 38.2 nM[1]。
HDAC6-IN-15 (50 μL; 48 h) 对 22RV1、MM1.S、MV4-11、JEKO-1 和 4T1 细胞具有抗肿瘤活性，IC50 值分别为 8.90 μM、11.90 μM、7.83 μM、4.80 μM 和 16.51 μM[1]。
HDAC6-IN-15（100、200、400、800 nM；24 h）剂量依赖性地诱导乙酰化 a-微管蛋白的积累[1]。
HDAC6-IN-15 (5, 10 μM; 24 h) 可诱导细胞凋亡[1]。
HDAC6-IN-15（4 mg/mL；48 h）表现出最佳的人血浆稳定性特征[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC6-IN-15 相关抗体:

Cell Proliferation Assay[1]

Cell Line: 22RV1, MM1.S, MV4-11, JEKO-1 and 4T1 cells
Concentration: 50 μL
Incubation Time: 48 h
Result: Showed moderate anti-proliferative activities in all the cancer cell lines.

Western Blot Analysis[1]

Cell Line: JEKO-1 cells; 4T1 cells
Concentration: 100, 200, 400, 800 nM; 5, 10 μM
Incubation Time: 24 h
Result: Significantly increase the levels of acetylated α-tubulin in a concentration dependent manner.
Slightly increased the levels of histone H3 and H4 acetylation.
Significantly increased the ratio of acetylated α-tubulin at the concentration of 800 nM.
Dramatically increased the levels of cleavage of PARP and caspase-3 in cells dose-dependently.

Apoptosis Analysis[1]

Cell Line: 4T1 cells
Concentration: 5, 10 μM
Incubation Time: 24 h
Result: Triggered apoptosis in 4T1 cells in a dose-dependent manner, in particularly undergoing early stage apoptosis upon 18 h treatment.
分子量

477.35

Formula

C25H28FFeN3O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC6-IN-15 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-15HDACHistone deacetylasesHistone deacetylase 6 (HDAC6)inhibitioncancerneurodegenerative diseasesInhibitorinhibitorinhibit

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产品名称：
HDAC6-IN-15
目录号：
HY-152235
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