2. Stem Cell/Wnt
  3. Hedgehog Smo
  4. Hedgehog IN-6

Hedgehog IN-6 (Compound Q29 ) 是一种 Hedgehog (Hh) 抑制剂，可用于癌症的研究。Hedgehog IN-6 通过与 Smoothened (Smo) 的富含半胱氨酸结构域 (CRD) 结合并阻断其胆固醇化来抑制 hedgehog (Hh) 通路。

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Hedgehog IN-6 Chemical Structure

Hedgehog IN-6 Chemical Structure

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Hedgehog IN-6 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Hedgehog IN-6 (Compound Q29) is a Hedgehog (Hh) inhibitor that can be used in cancer research. Hedgehog IN-6 inhibits the hedgehog (Hh) pathway by binding to the cysteine-rich domain (CRD) of Smoothened (Smo) and blocking its cholesterization[1].

体外研究
(In Vitro)

Q29 (1-10 μM；24 小时) 剂量依赖性地抑制 Shh-N 激活的 GLI1 蛋白表达[1]。
Q29 (1-10 μM；24 + 12 小时) 以剂量依赖性方式抑制 Hh 信号依赖性细胞增殖[1]。
在不同浓度的 Shh-N 存在下，Q29 抑制 Gli-荧光素酶活性，IC50 为 1.33 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Hedgehog IN-6 相关抗体:

Western Blot Analysis[1]

Cell Line: NIH 3T3 cells
Concentration: 1, 3, 10 μM
Incubation Time: 24 h
Result: Dose dependently decreased the protein and mRNA levels of endogenous Gli1.

Cell Proliferation Assay[1]

Cell Line: cGNP cells; medulloblastoma cells
Concentration: 1, 3, 10 μM
Incubation Time: 24 h+12h
Result: Dose dependently inhibited the growth of Shh-N-stimulated cGNP cells and medulloblastoma cells isolated from Ptch1+/P53/ mice.
体内研究
(In Vivo)

Q29 (90 mg/kg；口服管饲；每天两次；13 天) 可有效抑制 Ptch1+/P53/ 小鼠的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ptch1+/P53/ mice[1]
Dosage: 90 mg/kg
Administration: p.o.; twice daily; 13 days
Result: Effectively inhibited tumor growth and exhibited synergistic inhibition with vismodegib (15 mg/kg; HY-10440)
分子量

389.61

Formula

C25H43NO2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Hedgehog IN-6 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hedgehog IN-6Hedgehog IN6Hedgehog IN 6HedgehogSmoSmoothenedsmoothenedcysteine-rich domainbasal cell carcinomasvismodegibmedulloblastomacholesterylationPtch1+/P53/ micecGNP cellsmedulloblastoma cellsNIH 3T3 cellsInhibitorinhibitorinhibit

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目录号：
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