2. NF-κB
  3. IKK
  4. IKKβ-IN-3

IKKβ-IN-3 (Compound hit4) 是一种 IKKβ 抑制剂，其 IC50 值为 30.4 nM。IKKβ 是 NF-κB 信号通路中的关键酶，参与许多疾病的发生。IKKβ-IN-3 能够用于 CAF 诱导的关节炎的研究。

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IKKβ-IN-3 Chemical Structure

IKKβ-IN-3 Chemical Structure

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IKKβ-IN-3 相关抗体

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IKK-α IKK-β IKK IKKε TBK1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

IKKβ-IN-3 (Compound hit4) is a IKKβ inhibitor with an IC50 value of 30.4 nM. IKKβ is a key enzyme in the NF-κB signaling pathway and is involved in the development of many diseases. IKKβ-IN-3 can be used in the study of CAF-induced arthritis[1].

IC50 & Target

IKKβ

30.4 nM (IC50)

体内研究
(In Vivo)

IKKβ-IN-3 (Compound hit4) (10, 30 mg/kg; 1次，14天) 在完全 Freund 佐剂诱导的关节炎（AIA）大鼠模型中具有减轻炎症的作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adjuvant-induced arthritis (AIA) rat model[1]
Dosage: 10 and 30 mg/kg
Administration: gastric gavage (i.g.)
Result: At 30 mg/kg, significantly reduced rat paw swelling, inflammatory cell infiltration and hyperemia of the synovium.
Animal Model:
Dosage:
Administration:
Result:
分子量

321.41

Formula

C18H27NO4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

IKKβ-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IKKβ-IN-3IKKIκB kinaseI kappa B kinaseadjuvant-induced arthritis rat models， joint inflammationInhibitorinhibitorinhibit

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