Incomplete Freund's adjuvant (IFA)  (Synonyms: Montanide ISA-51)

Incomplete Freund's adjuvant (IFA) (Montanide ISA-51) is an immunoadjuvant emulsified with antigen by its discoverer Jules T. Freund. Incomplete Freund's adjuvant (IFA) does not contain inactivated tuberculosis bacilli and consists of petroleum jelly containing lanolin. Incomplete Freund's adjuvant (IFA) induces high antibody titers and long-lasting effector T cell responses with no long-term effects on collagen disease, tumors, or death. Complete Freund's adjuvant (CFA) (HY-153808) is another type of Freund's Adjuvant that stimulates a stronger immune response^[1][2].

Incomplete Freund's adjuvant (IFA) 可用于动物建模，构建持续性炎症性疼痛小鼠模型。

Incomplete Freund's adjuvant (IFA) 诱导抗体反应，而 Complete Freund's adjuvant (CFA) (HY-153808) 优先诱导自身抗原特异性反应^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

液体

Colorless to light yellow

弗氏不完全佐剂

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Melssen MM, et al. Peptide emulsions in incomplete Freund's adjuvant create effective nurseries promoting egress of systemic CD4+ and CD8+ T cells for immunotherapy of cancer. J Immunother Cancer. 2022 Sep;10(9):e004709.  [Content Brief]

  [2]. Fontes JA, et al. Complete Freund's adjuvant induces experimental autoimmune myocarditis by enhancing IL-6 production during initiation of the immune response. Immun Inflamm Dis. 2017 Jun;5(2):163-176.  [Content Brief]