2. Apoptosis GPCR/G Protein Others
  3. Angiotensin Receptor Apoptosis Isotope-Labeled Compounds
  4. Irbesartan-d7 hydrochloride

Irbesartan-d7 hydrochloride  (Synonyms: SR-47436-d7 hydrochloride; BMS-186295-d7 hydrochloride)

目录号: HY-B0202AS
产品使用指南

摩尔计算器

Irbesartan-d7 hydrochloride 是氘代标记的 Irbesartan hydrochloride (HY-B0202A)。Irbesartan (SR-47436) hydrochloride 是一种 Ang II 型 1 (AT1) 受体阻滞剂 (ARB)，具有口服活性。Irbesartan hydrochloride 可放松血管，降低血压，增加血液和氧气供应到心脏。 Irbesartan hydrochloride 可用于高血压、心力衰竭和糖尿病肾病的研究。

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Irbesartan-d<sub>7</sub> hydrochloride Chemical Structure

Irbesartan-d7 hydrochloride Chemical Structure

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Other Forms of Irbesartan-d7 hydrochloride:

Irbesartan-d7 hydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Irbesartan-d7 hydrochloride is deuterated labeled Irbesartan hydrochloride (HY-B0202A). Irbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease[1].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Irbesartan-d7 hydrochloride 相关抗体:
体内研究
(In Vivo)

Irbesartan hydrochloride (oral gavage; 50 mg/kg/d; once daily) reduces Th22 lymphocytosis and serum IL-22 level in Ang II-infused mice[2].
Irbesartan hydrochloride (oral gavage; 50 mg/kg/d; once daily) exerts obvious renoprotective effects[2].
Irbesartan hydrochloride (oral gavage; 50 mg/kg/d; once daily) relieves systemic inflammation and renal fibrosis in hypertension mice induced by Ang II[2].
Irbesartan hydrochloride (20 μM; for 3 h) can attenuate Th22 cells recruitment and IL-22 secretion, which might be through inhibiting chemotaxis in hypertensive renal injury mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

486.06

Formula

C26H24D7ClN6O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Irbesartan-d7 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Irbesartan-d7SR-47436-d7BMS-186295-d7Angiotensin ReceptorApoptosisIsotope-Labeled CompoundsAng II type 1 (AT1) receptor blocker (ARB)blood vesselsbloodheart failurechemotaxishypertensive renal injuryTh22 cellsdiabetic kidney diseaseInhibitorinhibitorinhibit

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