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JH530 是一种有效的巨泡式细胞死亡 (methuosis) 诱导剂，通过引起细胞内完全空泡化来抑制三阴性乳腺癌 (TNBC) 细胞的增殖。JH530 具有抗肿瘤活性，可用于癌症研究。

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JH530 Chemical Structure

JH530 Chemical Structure

CAS No. : 2928616-74-2

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JH530 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JH530 is an effective methuosis inducer that inhibits the triple-negative breast cancer (TNBC) cells proliferation by causing intracellular complete vacuolization. JH530 has anti-tumor activity and can be used for cancer research[1].

IC50 & Target

Methuosis[1]
体外研究
(In Vitro)

JH530 (compound 5c) (1 μM 或 2 μM; 24 h) 引起 HCC1806 细胞形态显著变化，其特征是细胞内空泡的积累，对 184B5 细胞的形态和细胞存活率几乎没有影响[1]。
JH530 (0.5, 1.0, 1.5 μM; 24 h) 引起巨泡式细胞死亡[1]。
JH530 (1 μM; 24 h) 有效抑制 TNBC 细胞的体外增殖[1]。
JH530 (1.5 μM; 24 h) 使 HCC1806 和 MDA-MB-468 细胞中 Rab7 和 Lamp1 的表达增加[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

JH530 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HCC1806, HCC1937, MDA-MB-468 cells
Concentration: 1 μM
Incubation Time: 24 hours
Result: Expressed remarkable anti-proliferative activities invitro, with the IC50s were 0.70 μM, 0.92 μM, and 1.03 μM for three TNBC cells HCC1806, MDA-MB-468, and HCC1937, respectively.

Cell Viability Assay[1]

Cell Line: HCC1806, 184B5
Concentration: 1 μM or 2 μM
Incubation Time: 24 hours
Result: Exhibited notable cellular morphological changes at 1 μM, characterized by the accumulation of intracellular vacuoles in HCC1806 cells.
Scarcely affected the morphology of 184B5 cells and cell viability.

Western Blot Analysis[1]

Cell Line: HCC1806; MDA-MB-468
Concentration: 0, 0.5, 1.0, 1.5 μM
Incubation Time: 24 hours
Result: Dose-dependently induced the increase of Rab7 and Lamp1 expression, and causes cell death by methuosis.

Immunofluorescence[1]

Cell Line: HCC1806, HCC1937, MDA-MB-468 cells
Concentration: 1.5 μM
Incubation Time: 24 hours
Result: Induced the increase of Rab7 and Lamp1 expression in HCC1806 and MDA-MB-468.
Induced the accumulation of vacuoles in most of the cell.
体内研究
(In Vivo)

JH530 (compound 5c) (2.5 mg/kg 或 5.0 mg/kg; 腹腔注射; 2 天 1 次，持续两周) 2.5 mg/kg 时显著抑制HCC1806 肿瘤重量，在 5 mg/kg 时表现出更明显的肿瘤抑制作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HCC1806 cell xenograft mouse model [1]
Dosage: 2.5 mg/kg, 5.0 mg/kg
Administration: Intraperitoneal injection (i.p.); once every 2 days
Result: Inhibits HCC1806 tumor weight at 2.5 mg/kg significantly, while exhibit more apparent tumor suppressive effects at 5 mg/kg[1].
分子量

530.44

Formula

C22H24BrN7O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JH530 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JH5302928616-74-2JH 530JH-530OthersTNBCHCC1806HCC1937MDA-MB-468xenograft models anti-tumorInhibitorinhibitorinhibit

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