2. Anti-infection
  3. HBV
  4. Junceellolide C

Junceellolide C 是一种 cccDNA 转录抑制剂。Junceellolide C 能抑制 HepAD38 细胞中 HBV DNA 的复制，且能显著降低细胞上清液中的 HBV RNA 水平，其 EC50 值分别为 5.19 和 3.52 μM。Junceellolide C 具有抗乙肝病毒活性。

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Junceellolide C Chemical Structure

Junceellolide C Chemical Structure

CAS No. : 121769-82-2

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Junceellolide C 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Junceellolide C is a transcription inhibitor of cccDNA. Junceellolide C inhibits HBV DNA replication and significantly decreases the level of supernatant HBV RNA with EC50 values of 5.19, 3.52 μM respectively in HepAD38 cells. Junceellolide C is a potent anti-HBV agent[1].

IC50 & Target

EC50: 2.27 μM (HBV DNA replication), 3.52 μM (HBV RNA decrease) in HBeAg cells[1]
体外研究
(In Vitro)

Junceellolide C (10 μM; 72 hours) inhibits HBV DNA replication and significantly decreases the level of supernatant HBV RNA in HepAD38 cells with EC50 values of 2.27, 3.52 μM, respectively[1].
Junceellolide C (10 μM; 8 days) can capable to inhibit HBV cccDNA replenishment and also to induce the existed HBV cccDNA degradation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Junceellolide C 相关抗体:

Cell Viability Assay[1]

Cell Line: HepAD38 cells
Concentration: 10 μM
Incubation Time: 72 h, 8 days
Result: Inhibited cccDNA transcription.
分子量

540.99

Formula

C26H33ClO10
CAS 号
结构分类
初始来源

South China Sea gorgonian Dichotella gemmacea
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Junceellolide C 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Junceellolide C121769-82-2HBVHepatitis B viruscccDNAHBV DNA replicationanti-HBVHepAD38Inhibitorinhibitorinhibit

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