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  4. Lacto-N-tetraose

Lacto-N-tetraose  (Synonyms: 乳糖-N-四糖)

目录号: HY-N9448
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摩尔计算器

Lacto-N-tetraose 是天然存在于人乳中的人乳低聚糖 (HMOs) 的重要核心结构。Lacto-N-tetraose 是由半乳糖、N-乙酰氨基葡萄糖和葡萄糖组成。Lacto-N-tetraose 具有益生元作用、免疫调节作用、抗炎作用、肠道细胞反应调节作用、抗菌活性和抗病毒活性。Lacto-N-tetraose 已被广泛添加到婴儿配方奶粉中。

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Lacto-N-tetraose Chemical Structure

Lacto-N-tetraose Chemical Structure

CAS No. : 14116-68-8

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Lacto-N-tetraose 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lacto-N-tetraose is the significant core structure of human milk oligosaccharides (HMOs) naturally existing in human milk. Lacto-N-tetraose is consist of galactose, N-acetylglucosamine, and glucose moieties. Lacto-N-tetraose has prebiotic effect, immune regulatory effect, anti-inflammatory effects, intestinal cell responses regulatory effect, antibacterial activity and antiviral activity. Lacto-N-tetraose has been widely added to infant formula[1].

体外研究
(In Vitro)

HMOs exhibits antimicrobial and antibiofilm activity against Streptococcus agalactiae, antibiofilm activity against Methicillin-resistant Staphylococcus aureus (MRSA), and antimicrobial activity against both Acinetobacter baumannii and Clostridium difficile[2].
Lacto-N-tetraose (500-2000 μg/mL) does not cause clastogenic or aneugenic signs in human peripheral blood lymphocytes, nor increase the percentage of micronucleated cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Lacto-N-tetraose 相关抗体:
体内研究
(In Vivo)

Lacto-N-tetraose (1000-4000 mg/kg; p.o.; daily for 90 days) does not show toxicity in neonatal SD rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female neonatal SD rats (housed together with dam until weaning after 21 days)[3]
Dosage: 1000, 25000 and 4000 mg/kg 
Administration: p.o.; daily for 90 days
Result: Did not show toxicity on clinical observations, body weight, food consumption, development and maturation, clinical pathology, organ weights or histopathology.
分子量

707.63

Formula

C26H45NO21
CAS 号
中文名称

乳糖-N-四糖
结构分类
初始来源

human
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Lacto-N-tetraose 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lacto-N-tetraose14116-68-8乳糖-N-四糖BacterialmilkoligosaccharidesHMOsprebioticimmuneanti-inflammatoryintestinal cellantibacterialantiviralInhibitorinhibitorinhibit

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