Leteprinim  (Synonyms: 来普利宁; AIT-082 free acid)

Leteprinim (AIT-082 free acid), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim is a hypoxanthine derivative neurotrophic agent. Leteprinim can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species^[1][2][3][4].

Leteprinim (5–50 ng/mL，24 和 48 小时) 可增强神经递质释放，增加 PC12 细胞中突触素的分泌^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Leteprinim (30 或 60 mg/kg，腹膜内注射，持续 7 天) 可保护大鼠免受红藻氨酸 (12 mg/kg) 诱导的海马神经元兴奋性毒性^[1]。
Leteprinim (60 mg/kg, i.p.) 在年轻和年老小鼠中提高工作记忆^[3]。
Leteprinim (60 mg/kg;腹腔注射;单剂量)显着减少缺氧缺血性脑损伤幼鼠中凋亡神经元的数量^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

327.29

C₁₅H₁₃N₅O₄

138117-50-7

来普利宁

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Di Iorio P, et al. AIT-082 is neuroprotective against kainate-induced neuronal injury in rats. Exp Neurol. 2001 Jun;169(2):392-9.  [Content Brief]

  [2]. Lahiri DK, et al. Effect of a memory-enhancing drug, AIT-082, on the level of synaptophysin. Ann N Y Acad Sci. 2000 Apr;903:387-93.  [Content Brief]

  [3]. Glasky AJ, et al. Effect of AIT-082, a purine analog, on working memory in normal and aged mice. Pharmacol Biochem Behav. 1994 Feb;47(2):325-9.  [Content Brief]

  [4]. Gencpınar P, et al. Effects of neotrofin on neonatal hypoxic ischemic brain injury. Neurosci Lett. 2011 Nov 14;505(2):205-10.  [Content Brief]