2. Membrane Transporter/Ion Channel Apoptosis
  3. Sodium Channel Ferroptosis
  4. Levobupivacaine

Levobupivacaine  (Synonyms: (S)-(-)-Bupivacaine)

目录号: HY-B0653
产品使用指南

摩尔计算器

Levobupivacaine ((S)-(-)-Bupivacaine) 是一种长效的酰胺类局部麻醉剂。Levobupivacaine 通过可逆性阻断神经元钠通道 (sodium channel) 发挥麻醉镇痛作用。Levobupivacaine 可抑制心血管等组织的传递和传导冲动，具有一定的心脏和中枢神经毒性。Levobupivacaine 在体内由细胞色素P450 (CYP450) 代谢。Levobupivacaine 也可通过 miR-489-3p/SLC7A11 信号通路诱导胃癌铁死亡 (ferroptosis)。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Levobupivacaine hydrochloride 通常具有更好的水溶性和稳定性。

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Levobupivacaine Chemical Structure

Levobupivacaine Chemical Structure

CAS No. : 27262-47-1

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Levobupivacaine 的其他形式现货产品:

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Levobupivacaine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Levobupivacaine ((S)-(-)-Bupivacaine) is a long-acting amide local anaesthetic. Levobupivacaine exerts anaesthetic and analgesic effects through reversible blockade of neuronal sodium channel. Levobupivacaine can inhibit impulse transmission and conduction in cardiovascular and other tissues, possessing certain cardiac and CNS toxicity. Levobupivacaine is metabolized by hepatic cytochrome P450 (CYP450) enzymes in vivo. Levobupivacaine can also induce ferroptosis by miR-489-3p/SLC7A11 signaling in gastric cancer[1][2][3].

IC50 & Target

Sodium channels, Ferroptosis[1][2]
体外研究
(In Vitro)

Levobupivacaine (0-4 mM; 24 h) does not affect the viability of GES-1 cells but inhibits the viability of HGC27 and SGC7901 cells[2].
Levobupivacaine (2 mM; 24, 48 or 72 h) enhances Erastin-induced inhibitory impact on HGC27 and SGC7901 cell viabilities; induces the levels of Fe2+, iron, and lipid ROS[2].
Levobupivacaine (2 mM; 24 h) enhances the expression of miR-489-3p in HGC27 and SGC7901 cells, increases the levels of Fe2+ and iron[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Levobupivacaine 相关抗体:

Cell Viability Assay[2]

Cell Line: GES-1, HGC27 and SGC790
Concentration: 0, 0.5, 1, 2 and 4 mM
Incubation Time: 24 h
Result: Did not affect the viability of normal gastric epithelial GES-1 cell lines but inhibited the viability of HGC27 and SGC7901 cells in a dose-dependent manner.

Cell Viability Assay[2]

Cell Line: HGC27 and SGC7901 (incubated with 5 μM erastin)
Concentration: 2 mM
Incubation Time: 24, 48 or 72 h
Result: Enhanced erastin-induced inhibitory impact on HGC27 and SGC7901 cell viabilities; induced the levels of Fe2+, iron, and lipid ROS.

RT-PCR[2]

Cell Line: HGC27 and SGC7901 (incubated with 5 μM erastin)
Concentration: 2 mM
Incubation Time: 24 h
Result: Enhanced the expression of miR-489-3p in HGC27 and SGC7901 cells, increased the levels of Fe2+ and iron.
体内研究
(In Vivo)

Levobupivacaine (40 μmol/kg; IP; once daily for 25 days) significantly inhibits SGC7901 cell growth, and enhances the lipid ROS accumulation[2].
Levobupivacaine (5 or 36 mg/kg; IP; single dosage) increases the latency to partial seizures and prevents the occurrence of generalized seizures at low dosage; reduces the latency to N-methyl-d-aspartate (NMDA)-induced seizures and increased seizure severity at high dosage[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD1 mice (30-35 g; induced epileptic seizures by injecting with NMDA)[3]
Dosage: 5 or 36 mg/kg
Administration: IP; single dosage
Result: Increased the latency to partial seizures and prevented the occurrence of generalized seizures at 5 mg/kg; reduced the latency to NMDA-induced seizures and increased seizure severity at 36 mg/kg.
Animal Model: SCID nude mice (6-8 weeks; subcutaneously injected with 5×106 SGC7901 cells)[2]
Dosage: 40 μmol/kg
Administration: IP; once daily for 25 days
Result: Significantly inhibited SGC7901 cell growth, and enhanced the lipid ROS accumulation.
Clinical Trial
分子量

288.43

Formula

C18H28N2O
CAS 号
中文名称

左布比卡因
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Levobupivacaine 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Levobupivacaine27262-47-1(S)-(-)-Bupivacaine左布比卡因Sodium ChannelFerroptosisNa channelsNa+ channelsanaestheticanalgesiccardiac toxicityCNS toxicityCYP450gastric cancerErastinNMDAInhibitorinhibitorinhibit

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